Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures
about
CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injuryPharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived NeuronsDesign, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Merging old and new perspectives on nicotinic acetylcholine receptorsTwo novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonistsThe antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines.Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule.Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation.Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum.Nicotinic acetylcholine receptors at the single-channel level.Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor.Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases.New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs.Effects of α7 Nicotinic Receptor Activation on Cell Survival in Rat Organotypic Hippocampal Slice Cultures.Boosting Endogenous Resistance of Brain to Ischemia.Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.
P2860
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P2860
Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Intrinsically low open probabi ...... at physiological temperatures
@ast
Intrinsically low open probabi ...... at physiological temperatures
@en
type
label
Intrinsically low open probabi ...... at physiological temperatures
@ast
Intrinsically low open probabi ...... at physiological temperatures
@en
prefLabel
Intrinsically low open probabi ...... at physiological temperatures
@ast
Intrinsically low open probabi ...... at physiological temperatures
@en
P2093
P2860
P356
P1476
Intrinsically low open probabi ...... at physiological temperatures
@en
P2093
Dustin K Williams
Matthew R Kimbrell
Roger L Papke
P2860
P304
P356
10.1124/MOL.112.080317
P50
P577
2012-07-24T00:00:00Z