Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors - Wikidata - wikimedia - TriplyDB

Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors

Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors

http://www.wikidata.org/entity/Q30371843

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Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.Merging old and new perspectives on nicotinic acetylcholine receptors Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study.Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines.An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline.Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.Use of an α3β4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties.Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor.An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs.Cracking the Betel Nut: Cholinergic Activity of Areca Alkaloids and Related Compounds.A Promising PET Tracer for Imaging of α₇ Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand.Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.

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P2860

Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors

http://www.wikidata.org/entity/Q30371843

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

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2008年論文

@zh-hk

2008年論文

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2008年論文

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2008年论文

@wuu

name

Multiple pharmacophores for th ...... 7-type acetylcholine receptors

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Multiple pharmacophores for th ...... 7-type acetylcholine receptors

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Multiple pharmacophores for th ...... 7-type acetylcholine receptors

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Multiple pharmacophores for th ...... 7-type acetylcholine receptors

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Multiple pharmacophores for th ...... 7-type acetylcholine receptors

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Molecular Pharmacology

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Multiple pharmacophores for th ...... 7-type acetylcholine receptors

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P2093

Fedra M Leonik

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Nicole A Horenstein

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Roger L Papke

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P2860

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist

An improved nicotinic pharmacophore and a stereoselective CoMFA-model for nicotinic agonists acting at the central nicotinic acetylcholine receptors labelled by

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment

Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand

Structure and activity of acetylcholine.

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

Overview of nicotinic receptors and their roles in the central nervous system.

(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor.

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.

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1496-1511

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scholarly article

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10.1124/MOL.108.048892

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6

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74

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2008-09-02T00:00:00Z

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23233619

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18768388

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2999882

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