Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage - Wikidata - wikimedia - TriplyDB

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

http://www.wikidata.org/entity/Q33366973

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Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy C/EBP and DEK coordinately regulate myeloid differentiation Regulation of C/EBPbeta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3 Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells.Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding The multifaceted functions of C/EBPα in normal and malignant haematopoiesis.C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.Effect of transcription-factor concentrations on leukemic stem cells.CD4 T follicular helper cell dynamics during SIV infection Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML.Pharmacogenetics of alkylator-associated acute myeloid leukemia.Acetylation of C/EBPα inhibits its granulopoietic function.The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation.Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators.Transcriptional dysregulation during myeloid transformation in AML.Dysregulation of the C/EBPalpha differentiation pathway in human cancer.Activator protein 2 alpha (AP2alpha) suppresses 42 kDa C/CAAT enhancer binding protein alpha (p42(C/EBPalpha)) in head and neck squamous cell carcinoma.An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation.Distinct microRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9-tetrahydrocannabinol in vivo: regulation of CCAAT/enhancer-binding protein α by microRNA-690.E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation.C/EBPα deregulation as a paradigm for leukemogenesis.FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis.CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity.Dual negative roles of C/EBPα in the expansion and pro-tumor functions of MDSCs.Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer.Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis.

P2860

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P2860

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

http://www.wikidata.org/entity/Q33366973

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Loss of C/EBP alpha cell cycle ...... neutrophil granulocyte lineage

@ast

Loss of C/EBP alpha cell cycle ...... neutrophil granulocyte lineage

@en

type

label

Loss of C/EBP alpha cell cycle ...... neutrophil granulocyte lineage

@ast

Loss of C/EBP alpha cell cycle ...... neutrophil granulocyte lineage

@en

prefLabel

Loss of C/EBP alpha cell cycle ...... neutrophil granulocyte lineage

@ast

Loss of C/EBP alpha cell cycle ...... neutrophil granulocyte lineage

@en

P1433

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P1433

Journal of Experimental Medicine

P1476

Loss of C/EBP alpha cell cycle ...... neutrophil granulocyte lineage

@en

P2093

Claus Nerlov

http://www.w3.org/2001/XMLSchema#string

Inge Damgaard

http://www.w3.org/2001/XMLSchema#string

Kristina Anderson

http://www.w3.org/2001/XMLSchema#string

Marie S Hasemann

http://www.w3.org/2001/XMLSchema#string

P2860

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

P304

85-96

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scholarly article

P356

10.1084/JEM.20050067

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P433

1

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P478

202

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P50

Bo Torben Porse

Sten Eirik W Jacobsen

K Theilgaard-Mönch

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2005-06-27T00:00:00Z

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P5875

7760937

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P698

15983063

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P932

2212897

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