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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

http://www.wikidata.org/entity/Q33378192

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Down syndrome and leukemia: insights into leukemogenesis and translational targets Acute Erythroleukemias, Acute Megakaryoblastic Leukemias, and Reactive Mimics: A Guide to a Number of Perplexing Entities Prognosis and management of acute myeloid leukemia in patients with Down syndrome Myeloid leukemia in Down syndrome Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update Hematological disorders and leukemia in children with Down syndrome.miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.The prenatal origins of cancer GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia.Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy.Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder.Down syndrome and malignancies: a unique clinical relationship: a paper from the 2008 william beaumont hospital symposium on molecular pathology MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971.Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22).Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21 Myeloid Proliferations Associated with Down Syndrome.Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation Constitutional aneuploidy and cancer predisposition.Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes.Malignancy in children with trisomy 21.Normal karyotype is a poor prognostic factor in myeloid leukemia of Down syndrome: a retrospective, international study.Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.Unique clinical and biological features of leukemia in Down syndrome children.Transient myeloproliferative disease: keeping a high index of suspicion.The impact of trisomy 21 on foetal haematopoiesis.Vesiculopustular eruption in neonatal transient myeloproliferative disorder.Transient myeloproliferative disorder in neonates without Down syndrome: case report and review.Haematopoietic development and leukaemia in Down syndrome.Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children.Stem and progenitor cell dysfunction in human trisomies.Transient myeloproliferative disorder in a newborn with down syndrome treated with rasburicase for the risk of development of tumor lysis syndrome: A case report.Evolution of myeloid leukemia in children with Down syndrome.Distinct GATA1 Point Mutations in Monozygotic Twins With Down Syndrome and Transient Abnormal Myelopoiesis From a Triplet Pregnancy: A Case Report and Review of Literature.A unique set of complex chromosomal abnormalities in an infant with myeloid leukemia associated with Down syndrome.

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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

http://www.wikidata.org/entity/Q33378192

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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

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Arnulf Pekrun

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Claudia Langebrake

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Dirk Reinhardt

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Katarina Macakova-Reinhardt

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Martin Zimmermann

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Michael Dworzak

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Ursula Creutzig

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P2860

Multiple sequence alignment with the Clustal series of programs

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression.

Myelodysplasia and acute myelogenous leukemia in Down's syndrome. A report of 40 children of the AML-BFM Study Group.

Evaluation of survival data and two new rank order statistics arising in its consideration.

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.

Transient leukaemia--a benign form of leukaemia in newborn infants with trisomy 21.

Pattern of malignant disorders in individuals with Down's syndrome.

Sequencing multimegabase-template DNA with BigDye terminator chemistry.

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