Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients. - Wikidata - wikimedia - TriplyDB

Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.

Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.

http://www.wikidata.org/entity/Q33400362

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Global genetic architecture of an erythroid quantitative trait locus, HMIP-2 Experimental generation of SNP haplotype signatures in patients with sickle cell anaemia Future alternative therapies for β-thalassemia.SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease.Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression Fetal hemoglobin in sickle cell anemia Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.A genetic score for the prediction of beta-thalassemia severity.Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer Fetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia.Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans.Genetic modifiers of sickle cell disease Genetic modifiers of β-thalassemia and clinical severity as assessed by age at first transfusion.Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease Genetic regulation of fetal haemoglobin in inherited bone marrow failure syndromes.Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.Persistent fetal gamma-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Agamma-globin gene.Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.Differences in the clinical and genotypic presentation of sickle cell disease around the world.Modifier genes in Mendelian disorders: the example of hemoglobin disorders.Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment.Association between XmnI Polymorphism and HbF Level in Sickle Cell Disease Patients from Chhattisgarh.Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients.Analysis of the rs35959442 polymorphism in Hb E/β-thalassemia in Guangxi Province of the Republic of China.Genomic variation in the MAP3K5 gene is associated with β-thalassemia disease severity and hydroxyurea treatment efficacy.Annotated definition of BCL11A and HMIP-2 haplotypes through the analysis of sicilian β-thalassemia patients with high levels of fetal hemoglobin.Genomic variants in the ASS1 gene, involved in the nitric oxide biosynthesis and signaling pathway, predict hydroxyurea treatment efficacy in compound sickle cell disease/β-thalassemia patients.Sickle cell disease: new opportunities and challenges in Africa.Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.Influences of genetic variation on fetal hemoglobin.A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia.

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P2860

Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.

http://www.wikidata.org/entity/Q33400362

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2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Genetic variation on chromosom ...... evels in sickle cell patients.

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Genetic variation on chromosom ...... evels in sickle cell patients.

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Genetic variation on chromosom ...... evels in sickle cell patients.

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Genetic variation on chromosom ...... evels in sickle cell patients.

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Genetic variation on chromosom ...... evels in sickle cell patients.

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Genetic variation on chromosom ...... evels in sickle cell patients.

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Genetic variation on chromosom ...... evels in sickle cell patients.

@en

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Colin A McKenzie

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Lisa E Creary

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Martin Farrall

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Neil A Hanchard

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Terrence E Forrester

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Veronica Taylor

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P2860

A second generation human haplotype map of over 3.1 million SNPs

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

Haploview: analysis and visualization of LD and haplotype maps

Genetic analysis of African populations: human evolution and complex disease

Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation

Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE).

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10.1371/JOURNAL.PONE.0004218

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19148297

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sickle-cell disease

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