DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. - Wikidata - wikimedia - TriplyDB

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

http://www.wikidata.org/entity/Q36800496

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Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin Current and future alternative therapies for beta-thalassemia major Customizing the genome as therapy for the β-hemoglobinopathies New insights from monogenic diabetes for "common" type 2 diabetes Genomic approaches to identifying targets for treating β hemoglobinopathies Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies Beta-globin gene haplotypes among cameroonians and review of the global distribution: is there a case for a single sickle mutation origin in Africa?Epigenetic regulation of fetal globin gene expression in adult erythroid cells Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients Erythro-megakaryocytic transcription factors associated with hereditary anemia Developmental and species-divergent globin switching are driven by BCL11A Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice Global genetic architecture of an erythroid quantitative trait locus, HMIP-2 Perspectives in Genetics and Sickle Cell Disease Prevention in Africa: Beyond the Preliminary Data from Cameroon Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.Genetic modifiers of Hb E/beta0 thalassemia identified by a two-stage genome-wide association study.Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia.Future alternative therapies for β-thalassemia.SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster A genome-wide association study of red blood cell traits using the electronic medical record.Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.Identification and characterization of small-molecule inducers of fetal hemoglobin.A call for policy action in sub-Saharan Africa to rethink diagnostics for pregnancy affected by sickle cell disease: differential views of medical doctors, parents and adult patients predict value conflicts in Cameroon.Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign.Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.How I use hydroxyurea to treat young patients with sickle cell anemia.Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study FOETAL HAEMOGLOBIN (HbF) STATUS IN ADULT SICKLE CELL ANAEMIA PATIENTS IN IBADAN, NIGERIA Amelioration of Sardinian beta0 thalassemia by genetic modifiers.Fetal globin expression is regulated by Friend of Prmt1.Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease.Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

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P2860

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

http://www.wikidata.org/entity/Q36800496

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DNA polymorphisms at the BCL11 ...... crises in sickle cell disease.

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DNA polymorphisms at the BCL11 ...... crises in sickle cell disease.

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DNA polymorphisms at the BCL11 ...... crises in sickle cell disease.

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DNA polymorphisms at the BCL11 ...... crises in sickle cell disease.

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DNA polymorphisms at the BCL11 ...... crises in sickle cell disease.

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DNA polymorphisms at the BCL11 ...... crises in sickle cell disease.

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Proceedings of the National Academy of Sciences of the United States of America

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DNA polymorphisms at the BCL11 ...... crises in sickle cell disease.

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Aderson S Araújo

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Antonio Cao

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Fernando F Costa

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Guillaume Lettre

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Joel N Hirschhorn

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Marcos André C Bezerra

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Stuart H Orkin

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Vijay G Sankaran

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P2860

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

PLINK: a tool set for whole-genome association and population-based linkage analyses

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Identification of ten loci associated with height highlights new biological pathways in human growth

Many sequence variants affecting diversity of adult human height

Bcl11a is essential for normal lymphoid development

Genome-wide association analysis identifies 20 loci that influence adult height

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

Heritability of cardiovascular and personality traits in 6,148 Sardinians

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33

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105

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David Schlessinger

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23138099

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sickle-cell disease

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2491485

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