The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
about
A systematic screen for micro-RNAs regulating the canonical Wnt pathwayWnt modulators in the biotech pipelineMammary Development and Breast Cancer: A Wnt PerspectiveFrizzled homolog proteins, microRNAs and Wnt signaling in cancerDuctal barriers in mammary epitheliumLRP5 and LRP6 in development and diseaseThe Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineageThe Wnt co-receptor Lrp6 is required for normal mouse mammary gland developmentWnt gene expression in human trabecular meshwork cells.LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.Wnt signaling in cancerUpregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasionWNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/β-catenin pathway.Key signaling nodes in mammary gland development and cancer: β-catenin.Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains.Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expressionCandidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases.Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.Lrp5 Has a Wnt-Independent Role in Glucose Uptake and Growth for Mammary Epithelial CellsCooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.Downregulation of human Wnt3 in gastric cancer suppresses cell proliferation and induces apoptosis.Physiological inhibitors of Wnt signaling.The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.Drugging Wnt signalling in cancerThe way Wnt works: components and mechanism.Targeting the WNT Signaling Pathway in Cancer Therapeutics.Potential Biomarkers in Diagnosis of Human Gastric Cancer.Molecular genetics and epigenetics of nonfamilial (sporadic) parathyroid tumours.Decreasing stearoyl-CoA desaturase-1 expression inhibits β-catenin signaling in breast cancer cells.Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingThe crossroads of breast cancer progression: insights into the modulation of major signaling pathways.Characterization of mammary-specific disruptions for Tph1 and Lrp5 during murine lactation.misspliced mutants of LRP5 support enhanced beta-catenin-dependent signalingAlternative splicing within the Wnt signaling pathway: role in cancer development.LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers.
P2860
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P2860
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
@ast
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
@en
type
label
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
@ast
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
@en
prefLabel
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
@ast
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
@en
P2093
P2860
P1433
P1476
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
@en
P2093
Anna-Karin Olsson
Gunnar Westin
Göran Akerström
Jessica Svedlund
P2860
P356
10.1371/JOURNAL.PONE.0004243
P407
P577
2009-01-22T00:00:00Z