about
Intrinsically disordered proteins are potential drug targetsUpdate of TTD: Therapeutic Target DatabasePerspectives on electrostatics and conformational motions in enzyme catalysisFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityShedding light on protein folding, structural and functional dynamics by single molecule studiesStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewHidden alternative structures of proline isomerase essential for catalysisAllosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.Fragment-Based Screen against HIV ProteaseRational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBDefining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxinsEnzyme Inhibition by Allosteric Capture of an Inactive ConformationA Reverse Binding Motif That Contributes to Specific Protease Inhibition by AntibodiesSmall Molecule Regulation of Protein Conformation by Binding in the Flap of HIV ProteaseBroad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesAtomic analysis of protein-protein interfaces with known inhibitors: the 2P2I databaseMechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAPMutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanismsThe impact of small molecule binding on the energy landscape of the intrinsically disordered protein C-mycCombined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas' diseaseThe role of dynamic conformational ensembles in biomolecular recognitionType 1 and Type 2 scenarios in hydrogen exchange mass spectrometry studies on protein-ligand complexes.Advances in Nuclear Magnetic Resonance for Drug Discovery.Recent excitements in protein NMR: Large proteins and biologically relevant dynamics.Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Inhibition of a viral enzyme by a small-molecule dimer disruptor.Structural interrogation of phosphoproteome identified by mass spectrometry reveals allowed and disallowed regions of phosphoconformation.Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.Allosteric regulation of protease activity by small molecules.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesDynameomics: a comprehensive database of protein dynamics.Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.Navigating the ribosome's metastable energy landscapeTargeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase.A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.An introduction to NMR-based approaches for measuring protein dynamics.A general protocol for the generation of Nanobodies for structural biologyInsights into the dynamics of HIV-1 protease: a kinetic network model constructed from atomistic simulations.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Trapping moving targets with small molecules.
@ast
Trapping moving targets with small molecules.
@en
type
label
Trapping moving targets with small molecules.
@ast
Trapping moving targets with small molecules.
@en
prefLabel
Trapping moving targets with small molecules.
@ast
Trapping moving targets with small molecules.
@en
P2860
P356
P1433
P1476
Trapping moving targets with small molecules.
@en
P2093
Charles S Craik
Gregory M Lee
P2860
P304
P356
10.1126/SCIENCE.1169378
P407
P577
2009-04-01T00:00:00Z