Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?
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Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moietyA cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylationA Strategy for Direct Chemical Activation of the Retinoblastoma ProteinDevelopment and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells.Epigenetic assays for chemical biology and drug discovery.High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.The essential roles of chemistry in high-throughput screening triageIntegrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.Metal impurities cause false positives in high-throughput screening campaignsBiochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.A Bead-Based Proximity Assay for BRD4 Ligand Discovery.Non-stoichiometric inhibition in integrated lead finding - a literature review.Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery.A sensitive luminescent assay for the histone methyltransferase NSD1 and other SAM-dependent enzymes.A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development.Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress.Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.Chemical motifs that redox cycle and their associated toxicityFocus on PAINS: false friends in the quest for selective anti-protozoal lead structures from Nature?
P2860
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P2860
Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?
description
2010 nî lūn-bûn
@nan
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Redox cycling compounds genera ...... hits or promiscuous artifacts?
@en
Redox cycling compounds genera ...... hits or promiscuous artifacts?
@nl
type
label
Redox cycling compounds genera ...... hits or promiscuous artifacts?
@en
Redox cycling compounds genera ...... hits or promiscuous artifacts?
@nl
prefLabel
Redox cycling compounds genera ...... hits or promiscuous artifacts?
@en
Redox cycling compounds genera ...... hits or promiscuous artifacts?
@nl
P2860
P1476
Redox cycling compounds genera ...... hits or promiscuous artifacts?
@en
P2093
Paul A Johnston
P2860
P304
P356
10.1016/J.CBPA.2010.10.022
P577
2010-11-11T00:00:00Z