Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors
about
A high throughput screen for RGS proteins using steady state monitoring of free phosphate formationAllosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986Flow Cytometry: Impact on Early Drug DiscoveryUse of flow cytometric methods to quantify protein-protein interactions.Development of a novel high-throughput screen and identification of small-molecule inhibitors of the Gα-RGS17 protein-protein interaction using AlphaScreen.Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteinsRegulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.MScreen: an integrated compound management and high-throughput screening data storage and analysis system.Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.Discovery of regulators of receptor internalization with high-throughput flow cytometry.A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteinsConformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse.Multiplex IP-FCM (immunoprecipitation-flow cytometry): Principles and guidelines for assessing physiologic protein-protein interactions in multiprotein complexes.Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell LinesRGS17: an emerging therapeutic target for lung and prostate cancers.Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers.Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells.Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal.Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) ProteinsRole of Cholinergic Innervation and RGS2 in Atrial Arrhythmia.Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family.A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex.Analysis of factors affecting the variability of a quantitative suspension bead array assay measuring IgG to multiple Plasmodium antigens
P2860
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P2860
Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Polyplexed flow cytometry prot ...... igm for RGS protein inhibitors
@ast
Polyplexed flow cytometry prot ...... igm for RGS protein inhibitors
@en
type
label
Polyplexed flow cytometry prot ...... igm for RGS protein inhibitors
@ast
Polyplexed flow cytometry prot ...... igm for RGS protein inhibitors
@en
prefLabel
Polyplexed flow cytometry prot ...... igm for RGS protein inhibitors
@ast
Polyplexed flow cytometry prot ...... igm for RGS protein inhibitors
@en
P2093
P2860
P356
P1476
Polyplexed flow cytometry prot ...... igm for RGS protein inhibitors
@en
P2093
David L Roman
Richard R Neubig
Shodai Ota
P2860
P304
P356
10.1177/1087057109336590
P577
2009-06-16T00:00:00Z