Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
about
Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseasesRGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytesMegakaryocyte biology and related disordersFunctional analysis of Asb-1 using genetic modification in miceEndoreplication: polyploidy with purposeThrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneIdentification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopeniaThe thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells.The contribution of mouse models to the understanding of constitutional thrombocytopeniaPathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromesSTAT5 in hematopoietic stem cell biology and transplantationEltrombopag for the treatment of aplastic anemia: current perspectivesModeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome EngineeringZinc finger protein, Hzf, is required for megakaryocyte development and hemostasisAgm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and developmentCXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infectionA critical function for B-Raf at multiple stages of myelopoiesisPoint mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- miceThe megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesisIncomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.A numerical analysis model for the interpretation of in vivo platelet consumption data.Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activityA mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominanceMutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopeniaCongenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii.Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.Thrombopoietin and platelet production in chronic immune thrombocytopenia.New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents.Congenital amegakaryocytic thrombocytopenia: a brief review of the literatureThrombopoietin and hematopoietic stem cells.Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potentialCrosstalk between Platelets and the Immune System: Old Systems with New DiscoveriesPlatelet ITAM signaling is critical for vascular integrity in inflammation.Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia.
P2860
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P2860
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
description
1996 nî lūn-bûn
@nan
1996 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մարտին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Deficiencies in progenitor cel ...... thrombopoietic receptor c-Mpl.
@ast
Deficiencies in progenitor cel ...... thrombopoietic receptor c-Mpl.
@en
type
label
Deficiencies in progenitor cel ...... thrombopoietic receptor c-Mpl.
@ast
Deficiencies in progenitor cel ...... thrombopoietic receptor c-Mpl.
@en
prefLabel
Deficiencies in progenitor cel ...... thrombopoietic receptor c-Mpl.
@ast
Deficiencies in progenitor cel ...... thrombopoietic receptor c-Mpl.
@en
P2093
P1433
P1476
Deficiencies in progenitor cel ...... thrombopoietic receptor c-Mpl.
@en
P2093
P304
P407
P577
1996-03-01T00:00:00Z