Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
about
A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1.Novel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration.Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cellsDeterminants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data.Proteolysis of platelet receptors in humans and other species.Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during SepsisADAM-17: the enzyme that does it all.TACE (ADAM17) inhibits Schwann cell myelination.Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathwayDiscovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.Shed GP of Ebola virus triggers immune activation and increased vascular permeabilityEndothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulusADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1).Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substratesShedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathwaysIdentification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells.Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.The role of proteases in regulating Eph/ephrin signaling.The Mouse-Specific Splice Variant mRAGE_v4 Encodes a Membrane-Bound RAGE That Is Resistant to Shedding and Does Not Contribute to the Production of Soluble RAGE.The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.The ADAMs family of proteases as targets for the treatment of cancer.Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin, in vitro.Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility.A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein.Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation.The role of Adams in Notch signaling.Proteomic identification of protease cleavage sites: cell-biological and biomedical applications.ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.Identification of cleavage sites leading to the shed form of the anti-aging protein klothoClinical implications of compounds designed to inhibit ECM-modifying metalloproteinases.Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activitiesRegulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function.Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis.Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
P2860
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P2860
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Active-site determinants of su ...... lloproteinases TACE and ADAM10
@ast
Active-site determinants of su ...... lloproteinases TACE and ADAM10
@en
type
label
Active-site determinants of su ...... lloproteinases TACE and ADAM10
@ast
Active-site determinants of su ...... lloproteinases TACE and ADAM10
@en
prefLabel
Active-site determinants of su ...... lloproteinases TACE and ADAM10
@ast
Active-site determinants of su ...... lloproteinases TACE and ADAM10
@en
P2860
P356
P1433
P1476
Active-site determinants of su ...... lloproteinases TACE and ADAM10
@en
P2093
Benjamin E Turk
P2860
P356
10.1042/BJ20090549
P407
P577
2009-10-23T00:00:00Z