Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7
about
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNSNeurobiological Insights from mGlu Receptor Allosteric Modulation.Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical NetworkCharacterization of an mGluR2/3 negative allosteric modulator in rodent models of depressionVU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyIdentification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behaviorSubstituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.Allosteric modulation of metabotropic glutamate receptors.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsDevelopment of allosteric modulators of GPCRs for treatment of CNS disordersOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationLabel-Free Receptor Assays.A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor.mGluR7 genetics and alcohol: intersection yields clues for addiction.A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signalingPractical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsAllosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indicationsThe Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies.Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications.Nociception modulation by supraspinal group III metabotropic glutamate receptors.Tetracycline-based system for controlled inducible expression of group III metabotropic glutamate receptors.Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Functional selectivity induced by mGlu₄ receptor positive allosteric modulation and concomitant activation of Gq coupled receptors.Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats.Negative Allosteric Modulators of mGlu Receptor as Putative Antipsychotic DrugsMetabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental DisordersLabel-Free Biosensors for Cell Biology
P2860
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P2860
Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Context-dependent pharmacology ...... abotropic glutamate receptor 7
@ast
Context-dependent pharmacology ...... abotropic glutamate receptor 7
@en
Context-dependent pharmacology ...... botropic glutamate receptor 7.
@nl
type
label
Context-dependent pharmacology ...... abotropic glutamate receptor 7
@ast
Context-dependent pharmacology ...... abotropic glutamate receptor 7
@en
Context-dependent pharmacology ...... botropic glutamate receptor 7.
@nl
prefLabel
Context-dependent pharmacology ...... abotropic glutamate receptor 7
@ast
Context-dependent pharmacology ...... abotropic glutamate receptor 7
@en
Context-dependent pharmacology ...... botropic glutamate receptor 7.
@nl
P2093
P2860
P356
P1476
Context-dependent pharmacology ...... abotropic glutamate receptor 7
@en
P2093
C David Weaver
Darren Orton
Jennifer E Ayala
Kari A Johnson
Nicole R Miller
Qingwei Luo
Richard Williams
Samir Saleh
P2860
P304
P356
10.1124/MOL.109.058768
P577
2009-12-21T00:00:00Z