Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
about
Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formationTargeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.Evaluating 5-nitrofurans as trypanocidal agents.An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugsEvaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugsNitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: in vivo studiesGene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruziAntitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.Transcriptome and Functional Genomics Reveal the Participation of Adenine Phosphoribosyltransferase in Trypanosoma cruzi Resistance to Benznidazole.Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agentsNovel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agentsBenznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.
P2860
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P2860
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@ast
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@en
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@nl
type
label
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@ast
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@en
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@nl
prefLabel
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@ast
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@en
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@nl
P2093
P2860
P921
P356
P1476
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
@en
P2093
Longqin Hu
Shane R Wilkinson
Xinghua Wu
P2860
P304
P356
10.1128/AAC.01213-09
P407
P577
2009-12-22T00:00:00Z