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Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer LesionsThe pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ERTrypanosoma brucei: TbRAB4 regulates membrane recycling and expression of surface proteins in procyclic forms.Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formationTargeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.Evaluating 5-nitrofurans as trypanocidal agents.An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugsThe endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system.New approaches to the microscopic imaging of Trypanosoma brucei.Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.A model for sequestration of the transmission stages of Plasmodium falciparum: adhesion of gametocyte-infected erythrocytes to human bone marrow cells.Dual role for transforming growth factor beta-dependent signaling in Trypanosoma cruzi infection of mammalian cells.Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.Both of the Rab5 subfamily small GTPases of Trypanosoma brucei are essential and required for endocytosis.Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway.Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation.Rab5 and Rab11 mediate transferrin and anti-variant surface glycoprotein antibody recycling in Trypanosoma brucei.Developmental variation in Rab11-dependent trafficking in Trypanosoma bruceiEvidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei.Rab4 is an essential regulator of lysosomal trafficking in trypanosomes.Synthesis and anti-parasitic activity of a novel quinolinone-chalcone series.Multiple tyrosine protein kinases structurally related to p56 lck are down-regulated following mitogenic stimulation of human T lymphocytes.The role of genomic location and flanking 3'UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei.Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.Two major tyrosine protein kinases of resting human T lymphocytes are down-regulated following mitotic stimulation
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description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
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name
Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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type
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
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Belinda S. Hall
@nl
Belinda S. Hall
@sl
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P1153
7401720519
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P31
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0000-0002-3753-1978