Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells
about
Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV ReservoirsSystems biology applied to vaccine and immunotherapy developmentAmiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cellsCD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza virusesImmunity to seasonal and pandemic influenza A virusesPredominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults.CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisPerforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressorsT-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infectionPrimary response against cytomegalovirus during antiviral prophylaxis with valganciclovir, in solid organ transplant recipientsIL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infectionActive evasion of CTL mediated killing and low quality responding CD8+ T cells contribute to persistence of brucellosis.Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infectionProfile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIVThe polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by ageImmune mechanisms of HIV control.HLA-A2 and B35 restricted hantaan virus nucleoprotein CD8+ T-cell epitope-specific immune response correlates with milder disease in hemorrhagic fever with renal syndromeThe nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responsesIncreased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression.Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection.Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patientsActivation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection.Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control.MyD88-dependent protective immunity elicited by adenovirus 5 expressing the surface antigen 1 from Toxoplasma gondii is mediated by CD8(+) T lymphocytes.Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression.Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques.Molecular regulation of effector and memory T cell differentiationT cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cellsCD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremiaTemporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers.Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicityIncreased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cellsPegylated interferon α enhances recovery of memory T cells in e antigen positive chronic hepatitis B patientsVertical T cell immunodominance and epitope entropy determine HIV-1 escape.Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size.High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response.
P2860
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P2860
Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Perforin and IL-2 upregulation ...... rus-specific human CD8 T cells
@ast
Perforin and IL-2 upregulation ...... rus-specific human CD8 T cells
@en
Perforin and IL-2 upregulation ...... us-specific human CD8 T cells.
@nl
type
label
Perforin and IL-2 upregulation ...... rus-specific human CD8 T cells
@ast
Perforin and IL-2 upregulation ...... rus-specific human CD8 T cells
@en
Perforin and IL-2 upregulation ...... us-specific human CD8 T cells.
@nl
prefLabel
Perforin and IL-2 upregulation ...... rus-specific human CD8 T cells
@ast
Perforin and IL-2 upregulation ...... rus-specific human CD8 T cells
@en
Perforin and IL-2 upregulation ...... us-specific human CD8 T cells.
@nl
P2093
P2860
P1433
P1476
Perforin and IL-2 upregulation ...... rus-specific human CD8 T cells
@en
P2093
Adam R Hersperger
Alexandra C Amick
Danielle Haney
Douglas Dolfi
E John Wherry
Gabriela Cosma
George Makedonas
Jay Gardner
Michael R Betts
Natalie Hutnick
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000798
P577
2010-03-05T00:00:00Z