Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?
about
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrateMaximizing the Therapeutic Potential of HSP90 InhibitorsTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesFunctional analysis of Hsp70 inhibitorsExploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketAllostery in the Hsp70 chaperone proteinsC-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balancesHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateContributions of academic laboratories to the discovery and development of chemical biology toolsExtracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasionInvestigating Apoptozole as a Chemical Probe for HSP70 InhibitionHsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription CompartmentsEvidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomasCombined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcomaA fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.A modified HSP70 inhibitor shows broad activity as an anticancer agent.Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Probing the probes: fitness factors for small molecule tools.Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide.Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor.Misfolded proteins: from little villains to little helpers in the fight against cancer.Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseasesHeat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic fluxProteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.Induction of heat-shock protein 70 expression by geranylgeranylacetone shows cytoprotective effects in cardiomyocytes of mice under humid heat stress.An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.Hsp90 molecular chaperone inhibitors: are we there yet?Recent progress in targeting cancer.Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes.Molecular chaperones in mammary cancer growth and breast tumor therapyGenome-Wide Analyses of Metal Responsive Genes in Caenorhabditis elegans.Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans.The HSP70 family and cancerKnock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells.Vorinostat in combination with bortezomib in patients with advanced malignancies directly alters transcription of target genes.Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.
P2860
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P2860
Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeting HSP70: the second po ...... otein and molecular chaperone?
@ast
Targeting HSP70: the second po ...... otein and molecular chaperone?
@en
Targeting HSP70: the second po ...... otein and molecular chaperone?
@nl
type
label
Targeting HSP70: the second po ...... otein and molecular chaperone?
@ast
Targeting HSP70: the second po ...... otein and molecular chaperone?
@en
Targeting HSP70: the second po ...... otein and molecular chaperone?
@nl
prefLabel
Targeting HSP70: the second po ...... otein and molecular chaperone?
@ast
Targeting HSP70: the second po ...... otein and molecular chaperone?
@en
Targeting HSP70: the second po ...... otein and molecular chaperone?
@nl
P2093
P50
P356
P1433
P1476
Targeting HSP70: the second po ...... otein and molecular chaperone?
@en
P2093
Isaac Westwood
Paul Workman
Rob L M van Montfort
P304
P356
10.4161/CC.9.8.11204
P577
2010-04-15T00:00:00Z