Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

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http://www.wikidata.org/entity/Q34747269
Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityExploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 InteractionCombined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcomaA fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone ComplementMutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.The Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisOverview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes.Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target.Disrupted hydrogen bond network and impaired ATPase activity in an Hsc70 cysteine mutant.Fluorescent-Linked Enzyme Chemoproteomic Strategy (FLECS) for Identifying HSP70 Inhibitors.Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.
P2860

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

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http://www.wikidata.org/entity/Q34747269
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2014 nî lūn-bûn
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2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Identification of an allosteri ...... form of heat shock protein 70.
@ast
Identification of an allosteri ...... form of heat shock protein 70.
@en
Identification of an allosteri ...... form of heat shock protein 70.
@nl
type
label
Identification of an allosteri ...... form of heat shock protein 70.
@ast
Identification of an allosteri ...... form of heat shock protein 70.
@en
Identification of an allosteri ...... form of heat shock protein 70.
@nl
prefLabel
Identification of an allosteri ...... form of heat shock protein 70.
@ast
Identification of an allosteri ...... form of heat shock protein 70.
@en
Identification of an allosteri ...... form of heat shock protein 70.
@nl
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Identification of an allosteri ...... form of heat shock protein 70.
@en
P2093
P2860
P304
P31
P356
10.1016/J.CHEMBIOL.2014.10.016
P433
P478
P50
P577
P698
P921
P932