The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate.
about
Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II functionSinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylationHistone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial developmentCrystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanismPR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionAn unexpected journey: lysine methylation across the proteomeCurrent chemical biology approaches to interrogate protein methyltransferasesCancer epigenetics drug discovery and development: the challenge of hitting the markGain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic interventionThe Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 RecognitionCrystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2SETD2: an epigenetic modifier with tumor suppressor functionalityExploring the developmental mechanisms underlying Wolf-Hirschhorn Syndrome: Evidence for defects in neural crest cell migrationThe histone methyltransferase MMSET regulates class switch recombinationNSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndromeThe histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny.The histone H3.3K36M mutation reprograms the epigenome of chondroblastomasA nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.MMSET: role and therapeutic opportunities in multiple myeloma.Chemical and biochemical approaches in the study of histone methylation and demethylationHuman LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylationThe histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.H3K36 methylation antagonizes PRC2-mediated H3K27 methylationThe role of genetics in the establishment and maintenance of the epigenome.Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.Neural crest specification and migration independently require NSD3-related lysine methyltransferase activity.In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.Histones: at the crossroads of peptide and protein chemistry.Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3Ascending the nucleosome face: recognition and function of structured domains in the histone H2A-H2B dimer.Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
P2860
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P2860
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The target of the NSD family o ...... n the nature of the substrate.
@ast
The target of the NSD family o ...... n the nature of the substrate.
@en
The target of the NSD family o ...... n the nature of the substrate.
@nl
type
label
The target of the NSD family o ...... n the nature of the substrate.
@ast
The target of the NSD family o ...... n the nature of the substrate.
@en
The target of the NSD family o ...... n the nature of the substrate.
@nl
prefLabel
The target of the NSD family o ...... n the nature of the substrate.
@ast
The target of the NSD family o ...... n the nature of the substrate.
@en
The target of the NSD family o ...... n the nature of the substrate.
@nl
P2093
P2860
P356
P1476
The target of the NSD family o ...... n the nature of the substrate.
@en
P2093
Chong-Feng Xu
Patrick Trojer
Peggie Cheung
Rui-Ming Xu
Thomas A Neubert
William J Drury
P2860
P304
34283-34295
P356
10.1074/JBC.M109.034462
P407
P577
2009-10-06T00:00:00Z