New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
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External and internal triggers of cell death in yeastNovel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding SiteAntiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype.Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancerDesign, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitorsSynthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agentsDesign, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents.An overview of tubulin inhibitors that interact with the colchicine binding siteCytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action.Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents.Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile.Apple can act as anti-aging on yeast cells.Arylthioindoles: Promising compounds against cancer cell proliferation.Hypothesis: is yeast a clock model to study the onset of humans aging phenotypes?3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.Synthesis and Free Radical Scavenging Activity of New Hydroxybenzylidene Hydrazines.Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.Iodine-catalyzed direct C-H thiolation of imidazo[1,5-a]quinolines for the synthesis of 3-sulfenylimidazo[1,5-a]quinolines.3-Acylindoles via palladium-catalyzed regioselective arylation of electron-rich olefins with indolesDesign, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach
P2860
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P2860
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
New arylthioindoles and relate ...... nd molecular modeling studies.
@ast
New arylthioindoles and relate ...... nd molecular modeling studies.
@en
New arylthioindoles and relate ...... nd molecular modeling studies.
@nl
type
label
New arylthioindoles and relate ...... nd molecular modeling studies.
@ast
New arylthioindoles and relate ...... nd molecular modeling studies.
@en
New arylthioindoles and relate ...... nd molecular modeling studies.
@nl
prefLabel
New arylthioindoles and relate ...... nd molecular modeling studies.
@ast
New arylthioindoles and relate ...... nd molecular modeling studies.
@en
New arylthioindoles and relate ...... nd molecular modeling studies.
@nl
P2093
P2860
P50
P356
P1476
New arylthioindoles and relate ...... and molecular modeling studies
@en
P2093
Bruno Maresca
Claudio Falcone
Ernest Hamel
Francesco Piscitelli
Lara Minelli
Michael C Edler
Roberto Saletti
Taradas Sarkar
Valerio Gatti
P2860
P304
P356
10.1021/JM900016T
P407
P50
P577
2009-12-01T00:00:00Z