Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

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http://www.wikidata.org/entity/Q35682298
Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding SiteNew Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitorsAntiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cellsAn overview of tubulin inhibitors that interact with the colchicine binding siteDesign, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agentMitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents.Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents, an update (2013-2015).Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels.Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents.Metal free sulfenylation and bis-sulfenylation of indoles: persulfate mediated synthesis.Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.Dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade.2,5-Diamide-Substituted Five-Membered Heterocycles: Challenging Molecular Synthons
P2860

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

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http://www.wikidata.org/entity/Q35682298
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Design and synthesis of 2-hete ...... improved metabolic stability.
@ast
Design and synthesis of 2-hete ...... improved metabolic stability.
@en
type
label
Design and synthesis of 2-hete ...... improved metabolic stability.
@ast
Design and synthesis of 2-hete ...... improved metabolic stability.
@en
prefLabel
Design and synthesis of 2-hete ...... improved metabolic stability.
@ast
Design and synthesis of 2-hete ...... improved metabolic stability.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Design and synthesis of 2-hete ...... h improved metabolic stability
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932