The clinical development of new mitotic inhibitors that stabilize the microtubule.
about
Ixabepilone for the treatment of solid tumors: a review of clinical dataSynthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance proteinNew arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.A novel synthetic analog of 5, 8-disubstituted quinazolines blocks mitosis and induces apoptosis of tumor cells by inhibiting microtubule polymerization.Iron complexation to oxygen rich marine natural products: a computational study.Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation.Update on options for treatment of metastatic castration-resistant prostate cancerBeyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins.Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.Enantioselective total synthesis of (-)-zampanolide, a potent microtubule-stabilizing agentFragment based group QSAR and molecular dynamics mechanistic studies on arylthioindole derivatives targeting the α-β interfacial site of human tubulin.Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.Radiosensitivity of human colon cancer cell enhanced by immunoliposomal docetaxel.New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitorsEpothilones in breast cancer: current status and future directions.Design, synthesis and biological evaluation of bridged epothilone D analogues.Targeting microtubules by natural agents for cancer therapy.Novel therapeutics for the management of castration-resistant prostate cancer (CRPC).Structural studies of taxol analogues for drug discovery.Novel brominated quinoline and pyrimidoquinoline derivatives as potential cytotoxic agents with synergistic effects of γ-radiation.Using cytochalasins to improve current chemotherapeutic approaches.A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton.Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.
P2860
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P2860
The clinical development of new mitotic inhibitors that stabilize the microtubule.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The clinical development of new mitotic inhibitors that stabilize the microtubule.
@ast
The clinical development of new mitotic inhibitors that stabilize the microtubule.
@en
type
label
The clinical development of new mitotic inhibitors that stabilize the microtubule.
@ast
The clinical development of new mitotic inhibitors that stabilize the microtubule.
@en
prefLabel
The clinical development of new mitotic inhibitors that stabilize the microtubule.
@ast
The clinical development of new mitotic inhibitors that stabilize the microtubule.
@en
P2093
P1433
P1476
The clinical development of new mitotic inhibitors that stabilize the microtubule.
@en
P2093
Dimitrios Colevas
Dominik Verdier-Pinard
Mace Rothenberg
Manuel Macapinlac
Sanjay Goel
Sridhar Mani
P304
P356
10.1097/01.CAD.0000131681.21637.B2
P577
2004-07-01T00:00:00Z