The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin
about
Rab7A is required for efficient production of infectious HIV-1The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domainHIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanismsBST-2/tetherin: a new component of the innate immune response to enveloped virusesAntiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteractionThe role of BST-2/Tetherin in host protection and disease manifestationHost restriction factors for hepatitis C virusUbiquitination-mediated regulation of interferon responsesStructural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformationsStructural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus ReleaseBone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivoExpression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradationMechanism of HIV-1 virion entrapment by tetherinHaploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligasesInterferon-induced tetherin restricts vesicular stomatitis virus release in neuronsCounteraction of the multifunctional restriction factor tetherinVpu and BST2: Still Not There Yet?Differential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.Modulation of HIV-1-host interaction: role of the Vpu accessory proteinMaturation and vesicle-mediated egress of primate gammaherpesvirus rhesus monkey rhadinovirus require inner tegument protein ORF52.Ultra structural characterisation of tetherin - a protein capable of preventing viral release from the plasma membraneA Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2.The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines.SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.Mouse knockout models for HIV-1 restriction factors.A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells.How Ebola virus counters the interferon system.Antagonism to human BST-2/tetherin by Sendai virus glycoproteins.Determinants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu proteinIdentification of alternatively translated Tetherin isoforms with differing antiviral and signaling activitiesThe interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?Vpu downmodulates two distinct targets, tetherin and gibbon ape leukemia virus envelope, through shared features in the Vpu cytoplasmic tail.The HERV-K human endogenous retrovirus envelope protein antagonizes Tetherin antiviral activityKaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR.Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system.Vpu binds directly to tetherin and displaces it from nascent virions.
P2860
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P2860
The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The RING-CH ligase K5 antagoni ...... osomal degradation of tetherin
@ast
The RING-CH ligase K5 antagoni ...... osomal degradation of tetherin
@en
The RING-CH ligase K5 antagoni ...... somal degradation of tetherin.
@nl
type
label
The RING-CH ligase K5 antagoni ...... osomal degradation of tetherin
@ast
The RING-CH ligase K5 antagoni ...... osomal degradation of tetherin
@en
The RING-CH ligase K5 antagoni ...... somal degradation of tetherin.
@nl
prefLabel
The RING-CH ligase K5 antagoni ...... osomal degradation of tetherin
@ast
The RING-CH ligase K5 antagoni ...... osomal degradation of tetherin
@en
The RING-CH ligase K5 antagoni ...... somal degradation of tetherin.
@nl
P2093
P2860
P1433
P1476
The RING-CH ligase K5 antagoni ...... osomal degradation of tetherin
@en
P2093
Alessandra Calvi
Claire Pardieu
Greg J Towers
Paul Bieniasz
Raphaël Vigan
Stuart J D Neil
Trinity Zang
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000843
P577
2010-04-15T00:00:00Z