Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening
about
Neuropeptide Y and posttraumatic stress disorder.Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonismCurrent approaches for the discovery of drugs that deter substance and drug abuse.Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3).Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonistsTherapeutic potential of neuropeptide Y (NPY) receptor ligands.Ligands of the neuropeptide Y Y2 receptor.Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YYRole of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents.Anticonvulsant neuropeptides as drug leads for neurological diseases.Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development.Neuropeptide Y receptors: how to get subtype selectivityNeuropeptides: metabolism to bioactive fragments and the pharmacology of their receptors.Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells.The importance of GLP-1 and PYY in resistant starch's effect on body fat in mice.[(3)H]UR-PLN196: a selective nonpeptide radioligand and insurmountable antagonist for the neuropeptide Y Y(2) receptor.A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists.Application of the guanidine-acylguanidine bioisosteric approach to argininamide-type NPY Y₂ receptor antagonists.Peripherally Administered Y2-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice.
P2860
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P2860
Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Selective and brain penetrant ...... cell high-throughput screening
@ast
Selective and brain penetrant ...... cell high-throughput screening
@en
Selective and brain penetrant ...... ell high-throughput screening.
@nl
type
label
Selective and brain penetrant ...... cell high-throughput screening
@ast
Selective and brain penetrant ...... cell high-throughput screening
@en
Selective and brain penetrant ...... ell high-throughput screening.
@nl
prefLabel
Selective and brain penetrant ...... cell high-throughput screening
@ast
Selective and brain penetrant ...... cell high-throughput screening
@en
Selective and brain penetrant ...... ell high-throughput screening.
@nl
P2093
P2860
P356
P1476
Selective and brain penetrant ...... cell high-throughput screening
@en
P2093
Becky A Mercer
Claes Wahlestedt
Michael Cameron
Peter Chase
Peter S Hodder
S Adrian Saldanha
Timothy P Spicer
P2860
P356
10.1124/MOL.109.058677
P577
2009-10-16T00:00:00Z