The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.
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Report on the use of non-clinical studies in the regulatory evaluation of oncology drugsMitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant TransformationUterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.Steroid hormone intervenes in the endometrial tumorigenesis of pten ablation.Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation.Mig-6 gene knockout induces neointimal hyperplasia in the vascular smooth muscle cell.Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling.Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironmentLoss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitmentThyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activityMitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death.Critical tumor suppressor function mediated by epithelial Mig-6 in endometrial cancer.Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell divisionReproductive tract function and dysfunction in women.Upregulation of mitogen-inducible gene 6 triggers antitumor effect and attenuates progesterone resistance in endometrial carcinoma cells.Traditional Approaches to Molecular Genetic Analysis.Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4.Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling.Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina.A pervasive role for MIG6 in restraining cell proliferation.Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis.Pik3ca is required for mouse uterine gland development and pregnancy.MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells.Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.A regional meeting continues to grow: the 2nd annual Michigan alliance for Reproductive Technologies and Science Conference.Mig-6 Mouse Model of Endometrial Cancer.Role of Mig-6 in hepatic glucose metabolism.Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT.
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The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The synergistic effect of Mig- ...... r development and progression.
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The synergistic effect of Mig- ...... r development and progression.
@en
The synergistic effect of Mig- ...... r development and progression.
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type
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The synergistic effect of Mig- ...... r development and progression.
@ast
The synergistic effect of Mig- ...... r development and progression.
@en
The synergistic effect of Mig- ...... r development and progression.
@nl
prefLabel
The synergistic effect of Mig- ...... r development and progression.
@ast
The synergistic effect of Mig- ...... r development and progression.
@en
The synergistic effect of Mig- ...... r development and progression.
@nl
P2093
P2860
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The synergistic effect of Mig- ...... er development and progression
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P2093
P2860
P2888
P304
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10.1038/ONC.2010.126
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P577
2010-04-26T00:00:00Z
P5875
P6179
1022719081