Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.
about
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell deathA ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of ParkinPost-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153Untangling the Manganese-α-Synuclein WebNeuropathological alterations in Alzheimer diseaseWhat macromolecular crowding can do to a proteinRole of α- and β-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathiesalpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson diseaseThe G336S variant in the human neurofilament-M gene does not affect its assembly or distribution: importance of the functional analysis of neurofilament variantsBiology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorderAcyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolismAbsence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice.Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesAmyloid diseases: abnormal protein aggregation in neurodegenerationAlterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.Integrated molecular landscape of Parkinson's diseaseTraumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus.A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction.Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins.Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.The interaction of unfolding α-lactalbumin and malate dehydrogenase with the molecular chaperone αB-crystallin: a light and X-ray scattering investigation.Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease.Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Metabolic states following accumulation of intracellular aggregates: implications for neurodegenerative diseases.Gaucher disease and the synucleinopathiesFragmentation of the Golgi apparatus induced by the overexpression of wild-type and mutant human tau forms in neurons.Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.Widespread nitration of pathological inclusions in neurodegenerative synucleinopathiesNeuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies.Possible alterations in β-Synuclein, the non-amyloidogenic homologue of α-Synuclein, during progression of sporadic α-synucleinopathiesBrain prostaglandin formation is increased by alpha-synuclein gene-ablation during global ischemia.Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice.
P2860
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P2860
Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Fatal attractions: abnormal pr ...... isease and Lewy body dementia.
@ast
Fatal attractions: abnormal pr ...... isease and Lewy body dementia.
@en
type
label
Fatal attractions: abnormal pr ...... isease and Lewy body dementia.
@ast
Fatal attractions: abnormal pr ...... isease and Lewy body dementia.
@en
prefLabel
Fatal attractions: abnormal pr ...... isease and Lewy body dementia.
@ast
Fatal attractions: abnormal pr ...... isease and Lewy body dementia.
@en
P2093
P356
P1476
Fatal attractions: abnormal pr ...... isease and Lewy body dementia.
@en
P2093
Iwatsubo T
Trojanowski JQ
P2888
P304
P356
10.1038/SJ.CDD.4400432
P577
1998-10-01T00:00:00Z