Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
about
Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved mannerTRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodiesA product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell deathLeucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Autoregulation of Parkin activity through its ubiquitin-like domainParkin accumulation in aggresomes due to proteasome impairmentHow does parkin ligate ubiquitin to Parkinson's disease?Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosisMolecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunctionProtein degradation pathways in Parkinson's disease: curse or blessingGIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activationThe parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodiesAssociation of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathiesParkin cleaves intracellular alpha-synuclein inclusions via the activation of calpainalpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson diseaseAggresome formation and neurodegenerative diseases: therapeutic implicationsParkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6The effects of oxidative stress on parkin and other E3 ligases.Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.Imaging genetics approach to Parkinson's disease and its correlation with clinical score.Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effectsLeucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's diseaseAlternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain.Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease.The epidemiology of dementia associated with Parkinson's disease.Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.Protein aggregation and degradation mechanisms in neurodegenerative diseasesEtiology of Parkinson's disease: Genetics and environment revisitedProtein-misfolding diseases and chaperone-based therapeutic approaches.Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.A meta-analysis of the relationship of the Parkin p.Val380Leu polymorphism to Parkinson's disease.Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease.Transcriptional regulation by nicotine in dopaminergic neurons.Recent advances in our understanding of neurodegeneration.Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.LRRK2 in Parkinson's disease and dementia with Lewy bodies.Disruption of protein quality control in Parkinson's disease.Annular alpha-synuclein oligomers are potentially toxic agents in alpha-synucleinopathy. Hypothesis.Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
P2860
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P2860
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
@ast
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
@en
type
label
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
@ast
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
@en
prefLabel
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
@ast
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
@en
P2093
P2860
P50
P1476
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
@en
P2093
Dennis J Selkoe
Hideki Shimura
J William Langston
Kenneth S Kosik
Lysia Forno
Matthew P Frosch
Michael G Schlossmacher
Miguel Medina
Nutan Sharma
Ronit Sharon
P2860
P304
P356
10.1016/S0002-9440(10)61113-3
P407
P577
2002-05-01T00:00:00Z