Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.
about
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.Ubiquitination by SAG regulates macrophage survival/death and immune response during infection.A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma.Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalizationErbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesisDepletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis.Suppression of tumor angiogenesis by targeting the protein neddylation pathway.MLN4924 therapy as a novel approach in cancer treatment modalities.SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses.MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis.Protein neddylation and its alterations in human cancers for targeted therapy.
P2860
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P2860
Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Endothelial deletion of Sag/Rb ...... and blocks tumor angiogenesis.
@ast
Endothelial deletion of Sag/Rb ...... and blocks tumor angiogenesis.
@en
type
label
Endothelial deletion of Sag/Rb ...... and blocks tumor angiogenesis.
@ast
Endothelial deletion of Sag/Rb ...... and blocks tumor angiogenesis.
@en
prefLabel
Endothelial deletion of Sag/Rb ...... and blocks tumor angiogenesis.
@ast
Endothelial deletion of Sag/Rb ...... and blocks tumor angiogenesis.
@en
P2093
P2860
P356
P1433
P1476
Endothelial deletion of Sag/Rb ...... and blocks tumor angiogenesis.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2013.473
P407
P577
2013-11-11T00:00:00Z
P5875
P6179
1053678618