Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.
about
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's diseaseA Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityRac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi exportLRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowthGTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationFunctional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyAn early endosome regulator, Rab5b, is an LRRK2 kinase substrateAdult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S miceLRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activityMutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal deathDysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegansMutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neuronsMouse Genetic Models of Human Brain DisordersThe associations between Parkinson's disease and cancer: the plot thickensMorphological changes of glutamatergic synapses in animal models of Parkinson's diseaseCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designThe involvement of microRNAs in neurodegenerative diseasesHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsThe role of the LRRK2 gene in ParkinsonismHigh LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brainNo dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblastsLRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainIdentification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motifThe promotion of neurite formation in Neuro2A cells by mouse Mob2 proteinPhosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's diseaseLeucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cellsSignal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticityProtective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia.The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeletonLRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
P2860
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P2860
Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.
@ast
Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.
@en
type
label
Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.
@ast
Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.
@en
prefLabel
Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.
@ast
Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.
@en
P2093
P2860
P50
P921
P1476
Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.
@en
P2093
Cai-Xia Long
Chengsong Xie
Hyun Jin Cho
Loukia Parisiadou
Xing-Long Gu
P2860
P304
13971-13980
P356
10.1523/JNEUROSCI.3799-09.2009
P407
P577
2009-11-01T00:00:00Z