Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. - Wikidata - wikimedia - TriplyDB

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

http://www.wikidata.org/entity/Q33595218

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1 Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2 Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7 A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily An early endosome regulator, Rab5b, is an LRRK2 kinase substrate Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons Mouse Genetic Models of Human Brain Disorders The associations between Parkinson's disease and cancer: the plot thickens Morphological changes of glutamatergic synapses in animal models of Parkinson's disease Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design The involvement of microRNAs in neurodegenerative diseases Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications The role of the LRRK2 gene in Parkinsonism High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia.The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.

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P2860

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

http://www.wikidata.org/entity/Q33595218

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.

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Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.

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Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.

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Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.

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Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.

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Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.

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JNEUROSCI.3799-09.2009

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Journal of Neuroscience

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Phosphorylation of ezrin/radix ...... ton in neuronal morphogenesis.

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Cai-Xia Long

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Chengsong Xie

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Hyun Jin Cho

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Lixin Sun

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Loukia Parisiadou

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Xian Lin

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Xing-Long Gu

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P2860

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Kinase activity of mutant LRRK2 mediates neuronal toxicity

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

LRRK2 in Parkinson's disease: protein domains and functional insights

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

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13971-13980

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44

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38067708

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phosphorylation

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2807632

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