Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress
about
Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseasesLRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activityLeucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like proteinALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium TriadRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseLoss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal traffickingMice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome traffickingAls2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalitiesAmyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor traffickingProgressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stressPhosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.Redox modifier genes and pathways in amyotrophic lateral sclerosis.Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neuronsGenetic rodent models of amyotrophic lateral sclerosisTransgenic animal models of neurodegeneration based on human genetic studies.N-WASP is required for membrane wrapping and myelination by Schwann cellsMice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1Rho-linked genes and neurological disorders.Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanismsAlsin and the molecular pathways of amyotrophic lateral sclerosisDeficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice.Amyotrophic lateral sclerosis: all roads lead to Rome.The involvement of DNA-damage and -repair defects in neurological dysfunctionTransgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration.ALS2/alsin knockout mice and motor neuron diseases.Genome-wide epigenetic regulation by early-life trauma.Mitochondria in neuroplasticity and neurological disorders.Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.Endocytic membrane trafficking and neurodegenerative disease.Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2.
P2860
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P2860
Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress
description
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im August 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/08/17)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/08/17)
@nl
наукова стаття, опублікована в серпні 2005
@uk
مقالة علمية (نشرت في 17-8-2005)
@ar
name
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@ast
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@en
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@nl
type
label
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@ast
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@en
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@nl
prefLabel
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@ast
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@en
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@nl
P2093
P2860
P1476
Loss of ALS2 function is insuf ...... es neurons to oxidative stress
@en
P2093
Chengsong Xie
Donald L Price
Fiona M Laird
Hongjin Wen
Hsueh-Cheng Chiang
Mohamed H Farah
Philip C Wong
P2860
P304
P356
10.1523/JNEUROSCI.1645-05.2005
P407
P577
2005-08-01T00:00:00Z