Recent advances on the pathogenesis of Huntington's disease.
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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcriptionHuntington's diseaseCellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic micePARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington's DiseaseSynchrotron infrared microspectroscopy detecting the evolution of Huntington's disease neuropathology and suggesting unique correlates of dysfunction in white versus gray brain matter.Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis.Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector.Mutant huntingtin can paradoxically protect neurons from death.Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's diseaseIndoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia.Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease.Caspases in Huntington's disease.Cell death mechanisms in neurodegeneration.Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy.Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington's disease ratsDysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice.The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.Huntingtin inclusion bodies are iron-dependent centers of oxidative events.Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain.Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease.Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells.Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid.Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death.Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes.Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.Anti-Inflammatory and Anti-Oxidant Potential of the Root Extract and Constituents of Doronicum austriacum.Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment.Stem cells as therapeutics for neurodegenerative disorders?Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant.
P2860
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P2860
Recent advances on the pathogenesis of Huntington's disease.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Recent advances on the pathogenesis of Huntington's disease.
@ast
Recent advances on the pathogenesis of Huntington's disease.
@en
type
label
Recent advances on the pathogenesis of Huntington's disease.
@ast
Recent advances on the pathogenesis of Huntington's disease.
@en
prefLabel
Recent advances on the pathogenesis of Huntington's disease.
@ast
Recent advances on the pathogenesis of Huntington's disease.
@en
P2093
P356
P1476
Recent advances on the pathogenesis of Huntington's disease.
@en
P2093
P356
10.1006/EXNR.1998.7006
P407
P577
1999-05-01T00:00:00Z