Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity - Wikidata - wikimedia - TriplyDB

Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity

Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity

http://www.wikidata.org/entity/Q33616168

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Animal models of β-hemoglobinopathies: utility and limitations The role of the -50 region of the human gamma-globin gene in switching Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development An approach to identify over-represented cis-elements in related sequences.Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.Humanized Mouse Model of Cooley's Anemia.Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch.The human gamma-globin TATA and CACCC elements have key, distinct roles in suppressing beta-globin gene expression in embryonic/fetal development.

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Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity

http://www.wikidata.org/entity/Q33616168

description

2000 nî lūn-bûn

@nan

2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Human gamma-globin gene promot ...... gene developmental specificity

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Human gamma-globin gene promot ...... gene developmental specificity

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type

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Human gamma-globin gene promot ...... gene developmental specificity

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Human gamma-globin gene promot ...... gene developmental specificity

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prefLabel

Human gamma-globin gene promot ...... gene developmental specificity

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Human gamma-globin gene promot ...... gene developmental specificity

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Nucleic Acids Research

P1476

Human gamma-globin gene promot ...... gene developmental specificity

@en

P2093

Ren J

http://www.w3.org/2001/XMLSchema#string

Ryan TM

http://www.w3.org/2001/XMLSchema#string

Sun CW

http://www.w3.org/2001/XMLSchema#string

Townes TM

http://www.w3.org/2001/XMLSchema#string

P2860

Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor

FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

The structure and evolution of the human beta-globin gene family

The "megaprimer" method of site-directed mutagenesis

Looping versus linking: toward a model for long-distance gene activation.

Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic mice

High-level erythroid expression of human alpha-globin genes in transgenic mice.

Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5' HS2 enhancer when in competition with the beta-promoter.

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2736-2740

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10.1093/NAR/28.14.2736

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14

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28

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10908330

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102642

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