Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
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Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT CellsEnhancing Human Immunodeficiency Virus-Specific CD8(+) T Cell Responses with Heteroclitic PeptidesThe multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsMore tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimersT-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen TargetingLoss of T Cell Antigen Recognition Arising from Changes in Peptide and Major Histocompatibility Complex Protein Flexibility: IMPLICATIONS FOR VACCINE DESIGNPeptide length determines the outcome of TCR/peptide-MHCI engagementStructural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.T-cell Receptor Specificity Maintained by Altered ThermodynamicsChemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of ImmunodominancePeptide modulation of class I major histocompatibility complex protein molecular flexibility and the implications for immune recognition.Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition.Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire.Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.Specific increase in potency via structure-based design of a TCR.Flanking residues are central to DO11.10 T cell hybridoma stimulation by ovalbumin 323-339.Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope.Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.Specific roles of each TCR hemichain in generating functional chain-centric TCR.Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.Identification of human leukemia antigen A*0201-restricted epitopes derived from epidermal growth factor pathway substrate number 8Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideIdentification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.Determinants of public T cell responses.TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines.Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.Augmenting antitumor T-cell responses to mimotope vaccination by boosting with native tumor antigens.Cross-reactivity of T cells and its role in the immune systemHotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.An Altered gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.Overview on poly(ADP-ribose) immuno-biomedicine and future prospects.Improving T cell responses to modified peptides in tumor vaccinesBias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.Structural and biophysical determinants of αβ T-cell antigen recognition.
P2860
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P2860
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Modification of MHC anchor res ...... binding and T cell recognition
@ast
Modification of MHC anchor res ...... binding and T cell recognition
@en
type
label
Modification of MHC anchor res ...... binding and T cell recognition
@ast
Modification of MHC anchor res ...... binding and T cell recognition
@en
prefLabel
Modification of MHC anchor res ...... binding and T cell recognition
@ast
Modification of MHC anchor res ...... binding and T cell recognition
@en
P2093
P2860
P50
P356
P1476
Modification of MHC anchor res ...... binding and T cell recognition
@en
P2093
Ania Skowera
Emma Gostick
Julia Ekeruche
Katherine J Adams
Katherine K Wynn
Linda Wooldridge
Mathew Clement
P2860
P304
P356
10.4049/JIMMUNOL.1000629
P407
P577
2010-07-16T00:00:00Z