Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.
about
Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia CellsNew pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancerMRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Identification of Novel Smoothened Ligands Using Structure-Based Docking.Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical TrialsToward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile.Hedgehog pathway inhibitors: a patent review (2009--present).Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.Hedgehog signaling in cancer stem cells: a focus on hematological cancers.Hedgehog inhibitors: a patent review (2013 - present).Strategies to target the Hedgehog signaling pathway for cancer therapy.Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.Synthesis and Smo Activity of Some Novel Benzamide Derivatives.Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor.
P2860
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P2860
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Virtual screening-based discov ...... ily as smoothened antagonists.
@ast
Virtual screening-based discov ...... ily as smoothened antagonists.
@en
type
label
Virtual screening-based discov ...... ily as smoothened antagonists.
@ast
Virtual screening-based discov ...... ily as smoothened antagonists.
@en
prefLabel
Virtual screening-based discov ...... ily as smoothened antagonists.
@ast
Virtual screening-based discov ...... ily as smoothened antagonists.
@en
P2093
P356
P1476
Virtual screening-based discov ...... mily as smoothened antagonists
@en
P2093
Andre Mann
Angele Schoenfelder
Antonio Solinas
Helene Faure
Hermine Roudaut
Martial Ruat
Maurizio Taddei
Tatiana Gorojankina
P304
P356
10.1124/MOL.110.065102
P577
2010-07-27T00:00:00Z