The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor - Wikidata - wikimedia - TriplyDB

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

http://www.wikidata.org/entity/Q33642959

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Biology of PXR: role in drug-hormone interactions Targeting xenobiotic receptors PXR and CAR for metabolic diseases Targeting xenobiotic receptors PXR and CAR in human diseases Reverse yeast two-hybrid system to identify mammalian nuclear receptor residues that interact with ligands and/or antagonists Activation of xenobiotic receptors: driving into the nucleus.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth in Japanese quail chicks Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice.Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.Noncanonical mechanisms to regulate nuclear receptor signaling.Pregnane X receptor and drug-induced liver injury.Overcoming drug resistance by regulating nuclear receptors.Regulation of porcine hepatic cytochrome p450 - implication for boar taint.Tissue-specific regulation of pregnane X receptor in cancer development and therapy.Acetylation of pregnane X receptor protein determines selective function independent of ligand activation.Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene Small-molecule modulators of the constitutive androstane receptor.Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Small-molecule modulators of PXR and CAR.Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation.Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo PXR antagonists and implication in drug metabolism.Role of CAR and PXR in xenobiotic sensing and metabolism.Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.

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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

http://www.wikidata.org/entity/Q33642959

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2007 nî lūn-bûn

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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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The phytoestrogen coumestrol i ...... the human pregnane X receptor

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Molecular Endocrinology

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The phytoestrogen coumestrol i ...... the human pregnane X receptor

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P2093

Bruce Wisely

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Bryan Goodwin

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Derek J Parks

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Ganjam V Kalpana

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Hao Li

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Hongwei Wang

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Jodi M Maglich

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John Roboz

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John T Moore

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Jon L Collins

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P2860

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

Role of LXRs in control of lipogenesis

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Cross-species and interassay comparisons of phytoestrogen action.

Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways.

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

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838-857

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scholarly article

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10.1210/ME.2007-0218

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4

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22

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Matthew R Redinbo

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2007-12-20T00:00:00Z

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5751810

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18096694

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5419551

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