Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.
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Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent mannerHuman T-lymphotropic virus type 1 open reading frame I p12(I) is required for efficient viral infectivity in primary lymphocytes.Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptationHuman immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism.The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells.Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissueCD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivoHuman immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.Differential pathogenesis of primary CCR5-using human immunodeficiency virus type 1 isolates in ex vivo human lymphoid tissue.Oxadiazols: a new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix proteinStimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptorsnef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes.Lentiviral Nef proteins manipulate T cells in a subset-specific mannerNef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation.Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways.In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss.Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes.HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo.Relationship between in vitro human immunodeficiency virus type 1 replication rate and virus load in plasma.Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivoThe inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef functionViremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functionsImpact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus.Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo.Modulation of HIV pathogenesis and T-cell signaling by HIV-1 NefEfficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques.Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques.The simian immunodeficiency virus deltaNef vaccine, after application to the tonsils of Rhesus macaques, replicates primarily within CD4(+) T cells and elicits a local perforin-positive CD8(+) T-cell response.Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection.Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses.Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection.Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor.SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
P2860
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P2860
Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Nef enhances human immunodefic ...... human lymphoid tissue ex vivo.
@ast
Nef enhances human immunodefic ...... human lymphoid tissue ex vivo.
@en
type
label
Nef enhances human immunodefic ...... human lymphoid tissue ex vivo.
@ast
Nef enhances human immunodefic ...... human lymphoid tissue ex vivo.
@en
prefLabel
Nef enhances human immunodefic ...... human lymphoid tissue ex vivo.
@ast
Nef enhances human immunodefic ...... human lymphoid tissue ex vivo.
@en
P2093
P2860
P1433
P1476
Nef enhances human immunodefic ...... human lymphoid tissue ex vivo
@en
P2093
Desrosiers R
Glushakova S
Margolis L
Suryanarayana K
P2860
P304
P577
1999-05-01T00:00:00Z