Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. - Wikidata - wikimedia - TriplyDB

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

http://www.wikidata.org/entity/Q33648347

about

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships Insulin receptor signaling in normal and insulin-resistant states Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25 YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice Lysine 63-linked ubiquitination is important for arachidonic acid-induced cellular adhesion and migration.Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span.Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation.Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure.TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways.TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation.TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease.TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-κB activation via mediating TAK1 degradation.TRAF molecules in cell signaling and in human diseases USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants.Role of the Helicobacter pylori-induced inflammatory response in the development of gastric cancer.The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look.The role of necroptosis, an alternative form of cell death, in cancer therapy.Molecular biology of atherosclerosis.Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK-dependent Egr-1 expression in EA.hy926 cells.Post-Translational Modifications of the TAK1-TAB Complex.Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.Helicobacter pylori activates NF-κB by inducing Ubc13-mediated ubiquitination of lysine 158 of TAK1.USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.

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P2860

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

http://www.wikidata.org/entity/Q33648347

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Lysine 63-linked polyubiquitin ...... appaB and JNK/AP-1 activation.

@ast

Lysine 63-linked polyubiquitin ...... appaB and JNK/AP-1 activation.

@en

type

label

Lysine 63-linked polyubiquitin ...... appaB and JNK/AP-1 activation.

@ast

Lysine 63-linked polyubiquitin ...... appaB and JNK/AP-1 activation.

@en

prefLabel

Lysine 63-linked polyubiquitin ...... appaB and JNK/AP-1 activation.

@ast

Lysine 63-linked polyubiquitin ...... appaB and JNK/AP-1 activation.

@en

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Journal of Biological Chemistry

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Lysine 63-linked polyubiquitin ...... appaB and JNK/AP-1 activation.

@en

P2093

Alex Chang

http://www.w3.org/2001/XMLSchema#string

Gufeng Xu

http://www.w3.org/2001/XMLSchema#string

Hong Zhang

http://www.w3.org/2001/XMLSchema#string

Jianhua Yang

http://www.w3.org/2001/XMLSchema#string

Jun Qin

http://www.w3.org/2001/XMLSchema#string

Michael D Schneider

http://www.w3.org/2001/XMLSchema#string

Min Xie

http://www.w3.org/2001/XMLSchema#string

Ningling Ge

http://www.w3.org/2001/XMLSchema#string

Renfang Mao

http://www.w3.org/2001/XMLSchema#string

Songbin Fu

http://www.w3.org/2001/XMLSchema#string

P2860

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination

PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation

Direct activation of protein kinases by unanchored polyubiquitin chains

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