A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.
about
Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10Opioid metabolismFlecainide induced peripheral neuropathyImpaired oxidation of debrisoquine in patients with perhexiline neuropathyThe effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4'-hydroxylase activity in human liver microsomesPharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquineTesting for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--histograms and probit plots.Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphismDebrisoquine oxidation polymorphism in patients with rheumatoid arthritis.Oxidative polymorphism of debrisoquine in Parkinson's diseaseTwo mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugsThe genetic control of sparteine and debrisoquine metabolism in man with new methods of analysing bimodal distributions.Polymorphic hydroxylation of perhexiline maleate in man.The genetic control of phenformin 4-hydroxylation.Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotypingThe potential and limitations of personalised medicine in primary care.Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms.Frequency of human CYP2D6 mutant alleles in a normal Chinese population.S-mephenytoin, sparteine and debrisoquine oxidation: genetic polymorphisms in a Turkish population.An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotypeEvidence for the polymorphic oxidation of debrisoquine and proguanil in a Khmer (Cambodian) populationThe effects of beta-adrenoceptor antagonists and levomepromazine on the metabolic ratio of debrisoquine.Lack of a relationship between the polymorphism of debrisoquine oxidation and lung cancerThe metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation.Variable metabolism of pinacidil: lack of correlation with the debrisoquine and trimethylamine C- and N-oxidative polymorphismsGenetically-determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect.Extensive oxidative metabolism of dextromethorphan in patients with almitrine neuropathy.Mephenytoin and sparteine oxidation: genetic polymorphisms in DenmarkInterindividual and interethnic differences in the demethylation and glucuronidation of codeine.Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation.Debrisoquine oxidation phenotype and susceptibility to lung cancer.Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population.Evidence for the polymorphic oxidation of debrisoquine in the Thai population.Quinidine kinetics after a single oral dose in relation to the sparteine oxidation polymorphism in man.A dose-effect study of the in vivo inhibitory effect of quinidine on sparteine oxidation in man.Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population.Polymorphism of dextromethorphan oxidation in a French populationDetermination of debrisoquine metabolic ratio from hourly urine collections in healthy volunteers.Debrisoquine oxidation in a Finnish population: the effect of oral contraceptives on the metabolic ratio.Enantioselectivity of 4-hydroxylation in extensive and poor metabolizers of debrisoquine.
P2860
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P2860
A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.
description
1980 nî lūn-bûn
@nan
1980 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1980 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1980年の論文
@ja
1980年論文
@yue
1980年論文
@zh-hant
1980年論文
@zh-hk
1980年論文
@zh-mo
1980年論文
@zh-tw
1980年论文
@wuu
name
A family and population study ...... in a white British population.
@ast
A family and population study ...... in a white British population.
@en
type
label
A family and population study ...... in a white British population.
@ast
A family and population study ...... in a white British population.
@en
prefLabel
A family and population study ...... in a white British population.
@ast
A family and population study ...... in a white British population.
@en
P2093
P2860
P356
P1476
A family and population study ...... in a white British population
@en
P2093
P2860
P304
P356
10.1136/JMG.17.2.102
P407
P577
1980-04-01T00:00:00Z