Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs
about
Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugsPharmacogenetic profile of xenobiotic enzyme metabolism in survivors of the Spanish toxic oil syndrome.Impact of New Genomic Technologies on Understanding Adverse Drug ReactionsPharmacogenetics: detecting sensitive populationsDeletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphismOxidative polymorphism of debrisoquine in Parkinson's diseaseGenetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans.Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liverFrequency of human CYP2D6 mutant alleles in a normal Chinese population.An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotypeDifferential foetal development of the O- and N-demethylation of codeine and dextromethorphan in manMetoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations.Stereoselective disposition of flecainide in relation to the sparteine/debrisoquine metaboliser phenotype.Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population.The AmpliChip CYP450 genotyping test: Integrating a new clinical tool.The debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotypeMolecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility.Pharmacogenetics: the slow, the rapid, and the ultrarapid.Pharmacogenetics of drug metabolising enzymes: importance for personalised medicine.The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition siteCytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.Cytochrome P450: what have we learned and what are the future issues?The human hepatic cytochromes P450 involved in drug metabolism.Endo-xenobiotic crosstalk and the regulation of cytochromes P450.Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of lung cancerA new frontier in personalized cancer therapy: mapping molecular changes.Complexities of CYP2D6 gene analysis and interpretation.Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk.Genetic differences in drug disposition.Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.Antidepressants and drug-metabolizing enzymes--expert group report.Phenotypic debrisoquine 4-hydroxylase activity among extensive metabolizers is unrelated to genotype as determined by the Xba-I restriction fragment length polymorphism.Use of probe drugs as predictors of drug metabolism in humans.Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.The influence of cytochrome P450 pharmacogenetics on disposition of common antidepressant and antipsychotic medications.Genetic predisposition to lung cancerDistinct phenotypes and genotypes of debrisoquine hydroxylation among Europeans and Chinese.The challenges of implementing pharmacogenomic testing in the clinic.Mutation frequencies of the cytochrome CYP2D6 gene in Parkinson disease patients and in families.
P2860
Q24683013-521D2A33-9A22-47CF-9DF0-191646CFC944Q24812002-46F50608-FD0D-4ED6-BE2F-BFA88948FD8AQ26787099-8DFC3AFD-A6E9-485C-A33D-7BD583A7E42EQ28767825-D59CA391-B171-4E09-AD08-0B0E5494FD6AQ33245041-655F828B-7AED-4F99-A8E4-69313F4AE637Q33588811-7348951D-5C34-4543-9776-951E32227A63Q33899650-7CAFD783-A3F3-4BFB-BA80-83DBCD57019CQ34246409-7D6C3583-263E-496A-AAE4-29B9A52C63B2Q34346439-5B47F775-4BC0-4E1B-985A-2A2D7D362A10Q34347560-6556BC80-907C-4145-9A39-F3B164CACE5EQ34358650-F8D33564-F2A2-4D1A-9094-8FFBAFAB4D7DQ34359016-59F56580-3721-4ACC-B2C1-703EAFE8BAB1Q34397985-F9FD15FF-2030-4EC4-8FFC-D897128AEBF5Q34403562-9583145A-C770-4173-B584-58496632FFC1Q34537662-A5FF9D18-F927-4922-B058-C5BA939BA03FQ34843826-AC5E9F03-5443-4A36-A039-142B3AA0F7C2Q34844253-9DBCE4A6-AFC3-4B53-A359-9C9372C98429Q35085298-804AB01A-267C-41D7-B55F-EF1B784D383FQ35127786-D8E49555-FB45-4FF3-88B1-C894CC5558D2Q35197475-21D9FCDD-F90C-436C-BD3B-80FE5DB05A35Q35198610-F08DC9F4-5D99-4A01-ADE8-965AB2E3648FQ35238375-CFAE1BC4-1C78-4B1D-9BCD-14D4B6988F7EQ35828009-A752C6E2-345E-4B93-AB72-2D161AEA26A0Q36258518-A30042B4-A2FA-4CD2-92DB-BC6D137876D2Q36929629-80631721-1D60-4089-A508-0A492299D670Q37296120-9E5455A4-37B1-457A-ABF6-C8991314FA1FQ37898108-9A9BBB61-7925-46A4-B94E-A63715CE729AQ38154914-D94CACC8-1049-495B-8984-2344A940558AQ39710934-C712199E-3121-4AC2-96B1-604165ABDA0DQ40645305-FF3AC80C-BA43-4D0D-AA17-04D0E5FE6C79Q40895567-CB124834-8854-4877-8DE4-1FBD601C18BBQ41019100-8B9010CC-DD10-4315-9A17-F8770294401BQ41135854-57A01BAC-424D-426D-A518-5CCEA7F95A03Q41361472-E7449026-5741-4281-95DF-94A5D620BD79Q41828306-A2913545-3F00-4F38-932A-A4A953D33840Q42047832-193CEBB0-391B-44E7-B99E-E7626FC01A1EQ42384248-D0B8235E-D16A-453B-A601-8348D87CE43CQ43205020-2B423587-D8F0-4906-A43D-62A6B98F258DQ47929031-BFEA657F-81E2-4C8F-A3CD-9955D39F59A0Q51005235-CF0A2871-BD93-4EE1-B857-4E9A59562F64
P2860
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs
description
1988 nî lūn-bûn
@nan
1988 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Two mutant alleles of the huma ...... f debrisoquine and other drugs
@ast
Two mutant alleles of the huma ...... f debrisoquine and other drugs
@en
type
label
Two mutant alleles of the huma ...... f debrisoquine and other drugs
@ast
Two mutant alleles of the huma ...... f debrisoquine and other drugs
@en
prefLabel
Two mutant alleles of the huma ...... f debrisoquine and other drugs
@ast
Two mutant alleles of the huma ...... f debrisoquine and other drugs
@en
P2093
P2860
P356
P1476
Two mutant alleles of the huma ...... f debrisoquine and other drugs
@en
P2093
P2860
P304
P356
10.1073/PNAS.85.14.5240
P407
P577
1988-07-01T00:00:00Z