Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

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http://www.wikidata.org/entity/Q33675186

Q33675186

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A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.Discovery of Potent and Selective Inhibitors of Toxoplasma gondii Thymidylate Synthase for Opportunistic Infections Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.

P2860

Q27345313-1B9A7922-B351-46C0-9AB0-F87ECC7135A9 Q27681485-2BFDBA3E-DFBA-4FD8-BE02-4594CFC2104A Q33636107-EA5698E8-2040-4A01-930C-8D88B51FEAB8 Q33872751-90A7350C-2707-49E0-95FB-10D5A85AFC5B Q34021465-6E4D223E-DCD4-4D58-8D11-4F68B28DA3CA Q35539229-9B9CC2AE-EB0D-436D-AB95-AC1D3DDB37CA Q35848191-279D0F66-EF45-4CCB-B2BF-9FC7EAFBC0D6 Q36096646-AC15883E-486C-4CCF-8E09-7E444FE53544 Q36213315-E009EDBD-9FD5-441D-8A53-E077CACBA6A3 Q36698678-235F59B0-F861-4609-BCEB-9220C4F30BB4 Q38700436-ACD8F9D4-8229-417B-B1B4-C95AAA5204A8 Q38713930-86B58B9F-F084-4C9B-AC64-96EF812FE58D Q38728583-57776C0A-71C9-42A6-8703-0593B5BC0325 Q48022535-6233D994-19B0-42C6-85F7-F46445543B26

P2860

Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

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http://www.wikidata.org/entity/Q33675186

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2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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