Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2
about
Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytesA High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration.Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil MigrationOpen access microfluidic device for the study of cell migration during chemotaxis.Glycogen synthase kinase-3 is required for efficient Dictyostelium chemotaxis.Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responsesPhosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay.PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes.TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis.Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motilityChemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium.Signaling mechanisms for chemotaxis.Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification.The small GTPases Ras and Rap1 bind to and control TORC2 activity.Protein kinase B gene homologue pkbR1 performs one of its roles at first finger stage of Dictyostelium.Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.Migration of Dictyostelium discoideum to the Chemoattractant Folic Acid.
P2860
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P2860
Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Chemotactic activation of Dict ...... ed functions of PDK1 and TORC2
@ast
Chemotactic activation of Dict ...... ed functions of PDK1 and TORC2
@en
type
label
Chemotactic activation of Dict ...... ed functions of PDK1 and TORC2
@ast
Chemotactic activation of Dict ...... ed functions of PDK1 and TORC2
@en
prefLabel
Chemotactic activation of Dict ...... ed functions of PDK1 and TORC2
@ast
Chemotactic activation of Dict ...... ed functions of PDK1 and TORC2
@en
P2093
P2860
P356
P1476
Chemotactic activation of Dict ...... ed functions of PDK1 and TORC2
@en
P2093
Alan R Kimmel
Jonathan Buggey
Xin-Hua Liao
P2860
P304
P356
10.1242/JCS.064022
P407
P577
2010-03-01T00:00:00Z