Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma. - Wikidata - wikimedia - TriplyDB

Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma.

Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma.

http://www.wikidata.org/entity/Q33706095

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Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase Functional genomics lead to new therapies in follicular lymphoma Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis (18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.Parallel gene expression profiling of mantle cell lymphoma - how do we transform 'omics data into clinical practice Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma A phase I/II study of the pan Bcl-2 inhibitor obatoclax mesylate plus bortezomib for relapsed or refractory mantle cell lymphoma.Identification of a human cyclin D1-derived peptide that induces human cytotoxic CD4 T cells Mouse models of cancer as biological filters for complex genomic data.Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer.Cyclin K and cyclin D1b are oncogenic in myeloma cells.Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis.Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma.Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia.The rb pathway and cancer therapeutics Mouse models of estrogen receptor-positive breast cancer Distinction between asymptomatic monoclonal B-cell lymphocytosis with cyclin D1 overexpression and mantle cell lymphoma: from molecular profiling to flow cytometry Consequence of the tumor-associated conversion to cyclin D1b Development of a murine model for blastoid variant mantle-cell lymphoma Relapsed and/or Refractory Mantle Cell Lymphoma: What Role for Temsirolimus?Impaired nuclear export of tumor-derived c-terminal truncated cyclin D1 mutant in ESCC cancer.Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice.Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.The cyclin D1b splice variant: an old oncogene learns new tricks.Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.AR, the cell cycle, and prostate cancer.Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.Molecular genetic characterization reveals new subsets of mantle cell lymphoma.New diagnosis of multiple myeloma in a patient with mantle cell lymphoma: Shared genetic factors or simple coincidence?Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b)Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.Cyclin D2 protein stability is regulated in pancreatic beta-cells.Nuclear cyclin D1: an oncogenic driver in human cancer.Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells.

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P2860

Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma.

http://www.wikidata.org/entity/Q33706095

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A B Gladden

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J A Diehl

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M A Wasik

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P Aggarwal

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P2860

New functional activities for the p21 family of CDK inhibitors

p53, the cellular gatekeeper for growth and division

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

Cancer cell cycles

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