Cyclin D2 protein stability is regulated in pancreatic beta-cells.
about
Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.The cell cycle as a brake for β-cell regeneration from embryonic stem cellsViral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclinsIslet biology, the CDKN2A/B locus and type 2 diabetes risk.Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S controlSuccessful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1.Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodentsAging induces a distinct gene expression program in mouse islets.Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channelsImmunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue.Type 2 diabetes and the aging pancreatic beta cell.Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activationSynergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication.Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regenerationPERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.Effect of aging on islet beta-cell function and its mechanisms in Wistar rats.Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage.Human pancreatic β-cell G1/S molecule cell cycle atlas.Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.Hepatocyte growth factor/c-Met signaling is required for β-cell regeneration.GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin ReceptorM2 macrophages promote beta-cell proliferation by up-regulation of SMAD7.Gastrointestinal hormones and the regulation of β-cell mass.GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice.Recurrent cyclin D2 mutations in myeloid neoplasms.Cyclin D2 is sufficient to drive β cell self-renewal and regeneration.Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet.β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis.Incretin Therapies Do Not Expand β-Cell Mass or Alter Pancreatic Histology in Young Male Mice.
P2860
Q24293466-3A5BF377-0859-42B7-88D8-AEC7ABDB8DC9Q27690967-669862B0-5996-46C3-9136-EF024D1B6FDAQ28076123-29C3CFE6-21D8-4E63-B3C6-0D41E511E2B9Q28480476-89D61669-82D8-478C-A550-E1ACA97369ABQ30251397-1C5F89F3-00E5-4270-98D7-9C8FD90A349DQ30541505-23322F0D-E972-413A-B515-095CD39969B5Q33578588-E84CC624-4114-4A23-AE22-B4AAEAFFDCA4Q33750760-3C1A8E2D-86B4-4076-BB9B-8628B68F2244Q34706953-A1228A86-759E-4EE2-B267-97DFB69FEBFEQ35046885-DC709492-6C99-4C9B-AF50-D0523FBBFE5CQ35175279-16A3925B-056B-4134-AD38-D233B1260B02Q35188218-73A67868-5443-4956-8BF5-6D00743B31E0Q35227199-1A2840A4-30F4-498D-90D0-41D199B9F73CQ35852524-171AA6ED-E361-411F-935A-E51FA743D80FQ35866737-2D259553-EE1D-4DFB-BC38-62ABE7632EBDQ36435206-BEC41A2B-801C-4523-92CD-F8FD7A0637D7Q36483092-98CC0F8D-8B95-4C40-BEF9-1E4ACE2CE732Q36908284-67BC7DC6-7454-4041-B33A-9F3EFA338E0CQ37014986-8CB2A367-0911-45F8-8BF6-D5C6B87CCE87Q37051098-AA68BCDF-8E81-456A-BDAB-36F8145AC99DQ37403319-17D60847-1E9B-4280-AF5A-F0A4F26A01BCQ37417676-DF32119C-F7A4-44E1-8BD2-A9ADDA813B3FQ37649339-2EBC8D0B-ADDD-4D70-B366-76F746435CFAQ37687626-7423CAA0-A059-4786-9815-AB782DD0B9E6Q37805600-D5B1BC88-50F8-4656-AA34-CB3FC7F8D270Q38773675-7DE40C05-0744-4F57-8C4E-0374F3F45AF7Q39429754-317479E5-668A-4478-8523-765CB7FAB877Q40153559-664C42BF-4901-475F-A297-E5ECEB2153CBQ46177727-44F0F67F-E03A-4969-B741-A2078F304804Q50642248-7EE862E6-D92E-494A-8BF1-46A59BF3C365Q50785281-0ED15B05-9083-44EC-92E7-415BF4A78E19Q52780711-D6D03420-DF1D-44F9-B085-38AE6AECA202
P2860
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
@en
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
@nl
type
label
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
@en
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
@nl
prefLabel
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
@en
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
@nl
P2093
P2860
P356
P1476
Cyclin D2 protein stability is regulated in pancreatic beta-cells.
@en
P2093
Daniel J Sartori
J Alan Diehl
Jake A Kushner
Lynn M Opare-Addo
Matthew M Rankin
Monica Teta
Simon Y Long
P2860
P304
P356
10.1210/ME.2009-0057
P577
2009-07-23T00:00:00Z