Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.
about
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNAThe role of RecQ helicases in non-homologous end-joiningDNA-PK autophosphorylation facilitates Artemis endonuclease activityDNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining systemWerner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylationUp-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinomaERCC1-XPF endonuclease facilitates DNA double-strand break repairDefective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient miceGenomic instability in mice lacking histone H2AXDeletion of the Pichia pastoris KU70 homologue facilitates platform strain generation for gene expression and synthetic biologyTagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80Computational analysis of retrovirus-induced scid cell death.Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation.Ku86 preserves chromatin integrity in cells adapted to high NaCl.Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis.Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells.Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rakDNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts.Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.Homologous and non-homologous recombination differentially affect DNA damage repair in mice.Genetic reporter system for oncogenic Igh-Myc translocations in mice.Confirmation of sable QTL that modifies the effects of the A(y) allele on yellow coat color on mouse chromosome 1.The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancerHyperthermia Induces Apoptosis of 786-O Cells through Suppressing Ku80 ExpressionRegulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymesStreptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells.Gene therapy strategies to improve the effectiveness of cancer radiotherapy.International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis.Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.DNA-damage repair; the good, the bad, and the ugly.Expression of Ku70 correlates with survival in carcinoma of the cervix.DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomesFrequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cellsKu70 and non-homologous end joining protect testicular cells from DNA damage.DNA repair in murine embryonic stem cells and differentiated cellsDNA double strand break repair via non-homologous end-joining.Radiation-hypersensitive cancer patients do not manifest protein expression abnormalities in components of the nonhomologous end-joining (NHEJ) pathway.
P2860
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P2860
Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Hypersensitivity of Ku80-defic ...... th, survival, and development.
@ast
Hypersensitivity of Ku80-defic ...... th, survival, and development.
@en
type
label
Hypersensitivity of Ku80-defic ...... th, survival, and development.
@ast
Hypersensitivity of Ku80-defic ...... th, survival, and development.
@en
prefLabel
Hypersensitivity of Ku80-defic ...... th, survival, and development.
@ast
Hypersensitivity of Ku80-defic ...... th, survival, and development.
@en
P2093
P2860
P356
P1476
Hypersensitivity of Ku80-defic ...... th, survival, and development.
@en
P2093
P2860
P304
13588-13593
P356
10.1073/PNAS.94.25.13588
P407
P577
1997-12-01T00:00:00Z