Caffeine and human DNA metabolism: the magic and the mystery. - Wikidata - wikimedia - TriplyDB

Caffeine and human DNA metabolism: the magic and the mystery.

Caffeine and human DNA metabolism: the magic and the mystery.

http://www.wikidata.org/entity/Q33715255

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Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B Germinating fission yeast spores delay in G1 in response to UV irradiation Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function.A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts.Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint.Phosphorylation of H2AX histones in response to double-strand breaks and induction of premature chromatin condensation in hydroxyurea-treated root meristem cells of Raphanus sativus, Vicia faba, and Allium porrum.Role of Macronutrients and Micronutrients in DNA Damage: Results From a Food Frequency Questionnaire.The enigmatic effects of caffeine in cell cycle and cancer Detrimental effects of UV-B radiation in a xeroderma pigmentosum-variant cell line Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence.Minimal detection of nuclear mutations in XP-V and normal cells treated with oxidative stress inducing agents.Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota Caffeine abolishes the ultraviolet-induced REV3 translesion replication pathway in mouse cells.Cyclobutane Pyrimidine Dimer Density as a Predictive Biomarker of the Biological Effects of Ultraviolet Radiation in Normal Human Fibroblast p53-Dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts.Identification of primary transcriptional regulation of cell cycle-regulated genes upon DNA damage DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.Human DNA polymerase eta activity and translocation is regulated by phosphorylation.Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.Development of DNA damage response signaling biomarkers using automated, quantitative image analysis.Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation.p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest.Caffeine extends yeast lifespan by targeting TORC1.Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression.Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR.DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint.Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects.

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Caffeine and human DNA metabolism: the magic and the mystery.

http://www.wikidata.org/entity/Q33715255

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2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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Caffeine and human DNA metabolism: the magic and the mystery.

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Caffeine and human DNA metabolism: the magic and the mystery.

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Caffeine and human DNA metabolism: the magic and the mystery.

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Caffeine and human DNA metabolism: the magic and the mystery.

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Caffeine and human DNA metabolism: the magic and the mystery.

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J.MRFMMM.2003.08.012

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Mutation Research

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Caffeine and human DNA metabolism: the magic and the mystery.

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Alexandra R Frank

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Dennis A Simpson

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Douglas D Luche

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Lea M Beaulieu

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Marila Cordeiro-Stone

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Miriam F Bryant

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Nana Nikolaishvili-Feinberg

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Sharon Doherty

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Timothy P Heffernan

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Tong Zhou

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P2860

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

Checkpoints: controls that ensure the order of cell cycle events

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

Caffeine inhibits the checkpoint kinase ATM

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85-102

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10.1016/J.MRFMMM.2003.08.012

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1-2

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