Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia. - Wikidata - wikimedia - TriplyDB

Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.

Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.

http://www.wikidata.org/entity/Q33722741

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Therapeutic approaches in myelofibrosis and myelodysplastic/myeloproliferative overlap syndromes Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1 RAS diseases in children Current management of juvenile myelomonocytic leukemia and the impact of RAS mutations Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.Molecular targets for the treatment of juvenile myelomonocytic leukemia.Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia.UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies Pathogenesis and consequences of uniparental disomy in cancer.Chronic myelomonocytic leukemia and atypical chronic myeloid leukemia: novel pathogenetic lesions.Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations.An evolutionary perspective on chronic myelomonocytic leukemia.Role of the ubiquitin proteasome system in hematologic malignancies.Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults.The importance of regulatory ubiquitination in cancer and metastasis.CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2.Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins Mutational analysis of RNA splicing machinery components in 206 children with myeloid malignancies.In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia.Novel approaches to diagnosis and treatment of Juvenile Myelomonocytic Leukemia.Origins of myelodysplastic syndromes after aplastic anemia.Molecular Diversity and Associated Phenotypic Spectrum of Germline CBL Mutations.Germline mutation of CBL is associated with moyamoya disease in a child with juvenile myelomonocytic leukemia and Noonan syndrome-like disorder.

P2860

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P2860

Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.

http://www.wikidata.org/entity/Q33722741

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Mutations of an E3 ubiquitin l ...... enile myelomonocytic leukemia.

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Mutations of an E3 ubiquitin l ...... enile myelomonocytic leukemia.

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Mutations of an E3 ubiquitin l ...... enile myelomonocytic leukemia.

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Mutations of an E3 ubiquitin l ...... enile myelomonocytic leukemia.

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Mutations of an E3 ubiquitin l ...... enile myelomonocytic leukemia.

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Mutations of an E3 ubiquitin l ...... enile myelomonocytic leukemia.

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Mutations of an E3 ubiquitin l ...... enile myelomonocytic leukemia.

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Anna M Jankowska

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Asahito Hama

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Atsushi Manabe

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Christine O'Keefe

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Heather Cazzolli

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Hideki Makishima

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Hideki Muramatsu

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Hiroshi Yagasaki

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Jaroslaw P Maciejewski

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Koji Kato

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P2860

Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS)

The Cbl interactome and its functions

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

A gain-of-function mutation of JAK2 in myeloproliferative disorders

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.

Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors.

Juvenile chronic myelogenous leukemia: report of the Italian Registry. Associazione Italiana di Ematologia Oncologia Pediatrica (AIEOP).

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

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