Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance - Wikidata - wikimedia - TriplyDB

Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance

Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance

http://www.wikidata.org/entity/Q33732451

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Contribution of Toll-like receptor signaling to germinal center antibody responses Siglecs and immune regulation Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment.Thymidine Phosphorylase Participates in Platelet Signaling and Promotes Thrombosis The Immunomodulatory Functions of Diacylglycerol Kinase ζ B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling Regulation of intracellular signaling by extracellular glycan remodeling.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.B-cell receptor signaling in diffuse large B-cell lymphoma.B cells and autoimmunity.Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.Lyn deficiency affects B-cell maturation as well as survival Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation B cell-specific loss of Lyn kinase leads to autoimmunity Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance.Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance TLR signaling in B-cell development and activation.Targeting CD22 in B-cell malignancies: current status and clinical outlook.Aberrant B-lymphocyte responses in lupus: inherent or induced and potential therapeutic targets.B-lymphocyte signalling abnormalities and lupus immunopathology.MAP Kinase Cascades in Antigen Receptor Signaling and Physiology.Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells.Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses.Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.

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P2860

Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance

http://www.wikidata.org/entity/Q33732451

description

2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Developmental acquisition of t ...... hway promotes B cell tolerance

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Developmental acquisition of t ...... hway promotes B cell tolerance

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Developmental acquisition of t ...... hway promotes B cell tolerance

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Developmental acquisition of t ...... hway promotes B cell tolerance

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Developmental acquisition of t ...... hway promotes B cell tolerance

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JIMMUNOL.0803941

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Journal of Immunology

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Developmental acquisition of t ...... hway promotes B cell tolerance

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P2093

Andrew J Gross

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Anil K Panigrahi

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Anthony L DeFranco

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Eline T Luning Prak

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Julia R Lyandres

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P2860

A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

Inhibition of the B cell by CD22: a requirement for Lyn

A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation

Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

Lyn tyrosine kinase: accentuating the positive and the negative

B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

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5382-5392

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scholarly article

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10.4049/JIMMUNOL.0803941

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9

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182

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24311638

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19380785

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2840041

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