A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.
about
It all comes together at the ends: telomerase structure, function, and biogenesisInsights into the evolution of mammalian telomerase: platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomesMany disease-associated variants of hTERT retain high telomerase enzymatic activityContributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzymeRNA-protein binding interface in the telomerase ribonucleoproteinInTERTpreting telomerase structure and functionStructure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactionsDirect involvement of the TEN domain at the active site of human telomeraseHuman telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.Telomerase mutations in smokers with severe emphysema.Single-stranded DNA repeat synthesis by telomeraseRNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency.Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human HepatocytesBiogenesis of telomerase ribonucleoproteinsThe common ancestral core of vertebrate and fungal telomerase RNAs.A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome.Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells.Telomerase and telomere-associated proteins: structural insights into mechanism and evolution.Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme.Telomerase Mechanism of Telomere Synthesis.Progress in Human and Tetrahymena Telomerase Structure Determination.In silico evaluation of TERT inhibition by anticancer drugs.DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity.
P2860
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P2860
A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
A novel motif in telomerase re ...... ddition rate and processivity.
@ast
A novel motif in telomerase re ...... ddition rate and processivity.
@en
type
label
A novel motif in telomerase re ...... ddition rate and processivity.
@ast
A novel motif in telomerase re ...... ddition rate and processivity.
@en
prefLabel
A novel motif in telomerase re ...... ddition rate and processivity.
@ast
A novel motif in telomerase re ...... ddition rate and processivity.
@en
P2093
P2860
P356
P1476
A novel motif in telomerase re ...... addition rate and processivity
@en
P2093
Christopher J Bley
Joshua D Podlevsky
Mingyi Xie
Xiaodong Qi
P2860
P304
P356
10.1093/NAR/GKP1198
P407
P577
2009-12-30T00:00:00Z