ATM: a mediator of multiple responses to genotoxic stress. - Wikidata - wikimedia - TriplyDB

ATM: a mediator of multiple responses to genotoxic stress.

ATM: a mediator of multiple responses to genotoxic stress.

http://www.wikidata.org/entity/Q33771767

about

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks The combined status of ATM and p53 link tumor development with therapeutic response Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system Characterization of DNA damage-stimulated self-interaction of Saccharomyces cerevisiae checkpoint protein Rad17p.ATM phosphorylates histone H2AX in response to DNA double-strand breaks Pathways governing G1/S transition and their response to DNA damage Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.Less efficient g2-m checkpoint is associated with an increased risk of lung cancer in African Americans.The Schizosaccharomyces pombe checkpoint kinases Chk1 and Cds1 are important for cell survival in response to cisplatin Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice In search of the tumour-suppressor functions of BRCA1 and BRCA2 RecQ helicases: caretakers of the genome The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation.Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants.MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster.Cell cycle checkpoints and their inactivation in human cancer.ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response.Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium.Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis.Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance ATM, a central controller of cellular responses to DNA damage.ATM function and telomere stability.Assessing TP53 status in human tumours to evaluate clinical outcome.Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice Association of the ATM gene polymorphisms with papillary thyroid cancer.ATM gene mutations in sporadic breast cancer patients from Brazil.Sensing of intermediates in V(D)J recombination by ATM.Ataxia telangiectasia mutated kinase plays a protective role in β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.

P2860

Q24291114-81A33411-D1C8-4208-B05C-262837318592 Q24291265-3A99336A-A8FD-4F75-81FA-7A1545E490D8 Q24652535-E97D4B75-1AC5-473C-BE00-8286D66B1581 Q24656275-D9472423-132C-4957-BFB2-B49C432D5B26 Q27932298-B36C8219-4F06-4890-A68B-68C4B6A8A7CD Q27933104-CEA93E1E-A456-427F-A2DB-04B449255DBF Q27934435-53514357-4355-460E-8BC9-5ED643786ACC Q27940131-0D909F9D-272C-40BB-A1F2-AFB4F1529448 Q28188651-EB4D27E6-DBE5-4F67-B956-DA173A64F369 Q28202348-7C09E4EB-6DC7-4B91-B7ED-38C78DD5E4BE Q28214146-AC5F6F03-2ED3-41A3-B51F-3356BB2C2DAB Q28343318-66FDBE91-8816-4EF4-9946-F529A6C8EC27 Q28387774-04306B28-CF31-4AB1-A366-4BADC92A44DA Q28475718-7F1D7A78-E49E-487C-83FD-0603BD0A21A8 Q28506612-BCBB02FD-7574-4BA1-AE3E-58D5A2F8665F Q28512255-3138E54B-62FB-460A-82F8-2152129C12A7 Q28587062-F9D0DEA6-A704-4A0C-BE10-653F643B8168 Q28593143-56901AFD-922A-40B3-85CB-45B969A197DA Q28748477-B5D9D86F-7BCB-4D08-B2E1-DB1692E360A4 Q29618390-E6C43AB3-D8F8-4008-AEF0-16F4218E1A2D Q31561068-C2811E4C-79FE-45F3-92B5-D2F93421CB64 Q33390327-3F6567FA-FD6A-49A9-8A6D-20C08D78766D Q33558779-6E42D6EA-261B-465D-ADB9-146410907018 Q33969092-209A1DFB-C8D8-4A15-9954-839314946856 Q34038351-4181574C-3EF4-4F27-BC53-21F732DE5AB9 Q34076478-0D77445E-309E-4D44-918F-EFE333CE9C43 Q34098413-514B1F62-4B92-4265-9937-99705A7D89A4 Q34144298-F4B66599-C166-4803-AC2B-EBF70C3A8BE8 Q34149479-06B10F3F-8EF6-4A11-B997-D1D85A29FFA4 Q34152941-D8F393C8-4245-49B2-9092-8746F4F785FD Q34175342-22966B0C-2484-4E61-ADBA-68EE5A979085 Q34176919-25E20136-DFE6-499A-ADD7-6E04F60180A9 Q34425440-A7CEC6F9-CA76-4093-B175-713789E3172F Q34535665-138B4E0F-250D-43A8-BE67-73AB2D7BDE42 Q34570100-A1EE626C-9E91-4262-9925-C9F35EA5A805 Q34584250-5C61772D-DF0F-4DB2-8BFB-C25FFBE7222A Q34909764-17C44DE8-16DE-4493-A22F-A6C5FCC3B632 Q34983335-957FC1FB-B1A8-47CB-B951-69907362072F Q35005088-B257D81D-EE54-4B3E-A61C-711CC19AAEA8 Q35019405-FD64A872-2158-4EC0-B6F0-A6223DF14DA6

P2860

ATM: a mediator of multiple responses to genotoxic stress.

http://www.wikidata.org/entity/Q33771767

description

1999 nî lūn-bûn

@nan

1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

ATM: a mediator of multiple responses to genotoxic stress.

@ast

ATM: a mediator of multiple responses to genotoxic stress.

@en

type

label

ATM: a mediator of multiple responses to genotoxic stress.

@ast

ATM: a mediator of multiple responses to genotoxic stress.

@en

prefLabel

ATM: a mediator of multiple responses to genotoxic stress.

@ast

ATM: a mediator of multiple responses to genotoxic stress.

@en

P1433

Q33771767-D65C9732-775A-451E-9AEF-89A36176EB64

P1476

Q33771767-6D78A0F7-C7FD-4833-BE20-4E49A348B9C8

P2093

Q33771767-A969A329-DB15-4FD2-A438-8C624DB53FFD

Q33771767-B75999EB-3D8A-4A90-9E2B-454E9F834540

P2860

Q33771767-0142B048-A458-4C12-A7EC-71CAAA84D544

Q33771767-02D28F4F-58C0-4525-99E0-A2F1F2252398

Q33771767-0ABFDCC7-CC5A-4DD0-8CAF-6D297D19D52C

Q33771767-0E1D9FB6-E5D4-4D24-A81B-66662B78307A

Q33771767-0F6F8439-6EFF-4370-928B-DAD7E803DA57

Q33771767-10426BE2-1265-4D2B-93B8-1C1A212E1020

Q33771767-1193C5CF-50FD-46DE-95FC-99A0BE99A93D

Q33771767-1571B2CF-2B8C-4E66-BCA5-9E8F3BC658F0

Q33771767-21114545-A50F-4707-BDDB-727E92316DB4

Q33771767-21A1E8F4-0BA9-448B-AAF8-2070FDBC97B5

P2888

Q33771767-5E7D44C3-F7CF-4A23-9A10-C1002C325C80

P304

Q33771767-0A3D1A90-BE78-42BA-B445-8AF9C0A76534

P31

Q33771767-7B24D535-B8D5-42FC-BF0F-1EDFC367AEA1

P356

Q33771767-7EA8A8BB-A053-4F03-92FB-F4637CDCB5DA

P407

Q33771767-1146B70F-4461-4F4A-95FD-29F3299FA6C9

P433

Q33771767-7768F633-9099-41A4-8FD0-4EA1BD36FB18

P478

Q33771767-25D61B92-F54A-4600-A492-D5CFBFC515FC

P577

Q33771767-4311E7E8-310F-47F3-BAB5-B6279E688ECD

P5875

Q33771767-32F0318C-722D-4E09-833B-9B6BCBF098A3

P6179

Q33771767-21BD1921-1F9D-49B0-872C-76E5692289FB

P698

Q33771767-831FC212-F0BE-4AD5-B403-BBAA8CD42F7B

P356

P1433

P1476

ATM: a mediator of multiple responses to genotoxic stress.

@en

P2093

Rotman G

http://www.w3.org/2001/XMLSchema#string

Shiloh Y

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

A role for ATR in the DNA damage-induced phosphorylation of p53

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

P2888

P304

6135-6144

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.ONC.1203124

http://www.w3.org/2001/XMLSchema#string

P407

P433

45

http://www.w3.org/2001/XMLSchema#string

P478

18

http://www.w3.org/2001/XMLSchema#string

P577

1999-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

12744049

http://www.w3.org/2001/XMLSchema#string

P6179

1040621853

http://www.w3.org/2001/XMLSchema#string

P698

10557105

http://www.w3.org/2001/XMLSchema#string