Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype. - Wikidata - wikimedia - TriplyDB

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.

http://www.wikidata.org/entity/Q33780763

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The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Stress-activated cap'n'collar transcription factors in aging and human disease Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Mechanism of chemical activation of Nrf2 Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy NRF2, cancer and calorie restriction miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells.Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress.NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma.Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.Carcinogenesis and transcriptional regulation through Maf recognition elements.Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells Seven in absentia homolog 2 (Siah2) protein is a regulator of NF-E2-related factor 2 (Nrf2)Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin The cytoprotective role of the Keap1-Nrf2 pathway.Involvement of RAGE, MAPK and NF-κB pathways in AGEs-induced MMP-9 activation in HaCaT keratinocytes.A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells.Utility of checklist to describe experimental methods for investigating molecular biomarkers.Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer.Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses.Transcriptional Regulation by Nrf2.NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells.Vitamin C protects piglet liver against zearalenone-induced oxidative stress by modulating expression of nuclear receptors PXR and CAR and their target genes.Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis.Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding

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P2860

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.

http://www.wikidata.org/entity/Q33780763

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Utility of siRNA against Keap1 ...... cer chemopreventive phenotype.

@ast

Utility of siRNA against Keap1 ...... cer chemopreventive phenotype.

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type

label

Utility of siRNA against Keap1 ...... cer chemopreventive phenotype.

@ast

Utility of siRNA against Keap1 ...... cer chemopreventive phenotype.

@en

prefLabel

Utility of siRNA against Keap1 ...... cer chemopreventive phenotype.

@ast

Utility of siRNA against Keap1 ...... cer chemopreventive phenotype.

@en

P1433

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Proceedings of the National Academy of Sciences of the United States of America

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Utility of siRNA against Keap1 ...... cer chemopreventive phenotype.

@en

P2093

Christopher D Lindsay

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Lesley I McLellan

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Tim W P Devling

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P2860

Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals

MicroRNAs: small RNAs with a big role in gene regulation

Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response e

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

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102

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Michael McMahon

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7858479

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15883370

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1091750

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